SynthesisHuman brain mapping2015
Neurofunctional topography of the human hippocampus.
Synthesis in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Pooled it
- Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis.Neuroscience and biobehavioral reviews · 2016Pooled it
- Acupuncture was associated with improved functional connectivity of the left hippocampal perceptual subregion in amnestic mild cognitive impairment.Brain imaging and behavior · 2026Trial
- rTMS modulates precuneus-hippocampal subregion circuit in patients with subjective cognitive decline.Aging · 2020Trial
- Increased hippocampal tail volume predicts depression status and remission to anti-depressant medications in major depression.Molecular psychiatry · 2018Trial
- Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula.Translational psychiatry · 2026Article
- From MRI to 3D printing: a tangible neuroeducational tool for visualizing hippocampal morphology and Alzheimer's disease progression.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Disentangling structure-function relationships between the human hippocampus and the whole brain using track-weighted dynamic functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal-hippocampal pathways underlying adolescent resilience.European child & adolescent psychiatry · 2025Article
- Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning.CNS neuroscience & therapeutics · 2025Article
- Dorsal-Caudal and Ventral Hippocampi Target Different Cell Populations in the Medial Frontal Cortex in Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal gray matter volume alterations in patients with first-episode and recurrent major depressive disorder and their associations with gene profiles.BMC psychiatry · 2025Article
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Multimodal MRI reveals distinct hippocampal subregional alterations inFrontiers in aging neuroscience · 2025Article
- Article
- Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy.Psychoradiology · 2024Article
- Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study.Frontiers in psychiatry · 2024Article
- Mapping the macrostructure and microstructure of the in vivo human hippocampus using diffusion MRI.Human brain mapping · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Much of what was assumed about the functional topography of the hippocampus was derived from a single case study over half a century ago. Given advances in the imaging sciences, a new era of discovery is underway, with potential to transform the understanding of healthy processing as well as the ability to treat disorders. Coactivation-based parcellation, a meta-analytic approach, and ultra-high field, high-resolution functional and structural neuroimaging to characterize the neurofunctional topography of the hippocampus was employed. Data revealed strong support for an evolutionarily preserved topography along the long-axis. Specifically, the left hippocampus was segmented into three distinct clusters: an emotional processing cluster supported by structural and functional connectivity to the amygdala and parahippocampal gyrus, a cognitive operations cluster, with functional connectivity to the anterior cingulate and inferior frontal gyrus, and a posterior perceptual cluster with distinct structural connectivity patterns to the occipital lobe coupled with functional connectivity to the precuneus and angular gyrus. The right hippocampal segmentation was more ambiguous, with plausible 2- and 5-cluster solutions. Segmentations shared connectivity with brain regions known to support the correlated processes. This represented the first neurofunctional topographic model of the hippocampus using a robust, bias-free, multimodal approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.