ArticleVirus genes2015
Genetic characterization of natural reassortant H4 subtype avian influenza viruses isolated from domestic ducks in Zhejiang province in China from 2013 to 2014.
Article in Virus genes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Epidemiological, phylogenetic, and pathogenicity analysis of H4 subtype avian influenza viruses in China, 2011-2022.Virologica Sinica · 2025Article
- Emerging zoonotic potential of H4N1 avian influenza virus: enhanced human receptor binding and replication via novel mutations.Virology journal · 2025Article
- Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China.Virology journal · 2024Article
- Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study.Viruses · 2024Article
- A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses.Heliyon · 2023Article
- Glycosylation of H4 influenza strains with pandemic potential and susceptibilities to lung surfactant SP-D.Frontiers in molecular biosciences · 2023Article
- South American H4N2 influenza A virus improved replication in chicken trachea after low number of passages.Frontiers in veterinary science · 2023Article
- Survey of low pathogenic avian influenza viruses in live poultry markets in Guangxi Province, Southern China, 2016-2019.Scientific reports · 2021Article
- Isolation and characterization of H4N6 avian influenza viruses from mallard ducks in Beijing, China.PloS one · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The H4 subtype of the influenza virus was first isolated in 1999 from pigs with pneumonia in Canada. H4 avian influenza viruses (AIVs) are able to cross the species barrier to infect humans. In order to better understand the genetic relationships between H4 AIV strains circulating in Eastern China and other AIV strains from Asia, a survey of domestic ducks in live poultry markets was undertaken in Zhejiang province from 2013 to 2014. In this study, 23 H4N2 (n = 14) and H4N6 (n = 9) strains were isolated from domestic ducks, and all eight gene segments of these strains were sequenced and compared to reference AIV strains available in GenBank. The isolated strains clustered primarily within the Eurasian lineage. No mutations associated with adaption to mammalian hosts or drug resistance was observed. The H4 reassortant strains were found to be of low pathogenicity in mice and able to replicate in the lung of the mice without prior adaptation. Continued surveillance is required, given the important role of domestic ducks in reassortment events leading to new AIVs.
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