ArticleScientific reports2015
Photo-activatable Cre recombinase regulates gene expression in vivo.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 83 citations in OpenAlex.
- Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics.Science advances · 2026Article
- Photocaged FLP recombinase for precise spatio-temporal control of gene expression.Nucleic acids research · 2026Article
- Enhancing the performance of Magnets photosensors.Nature communications · 2026Article
- Multiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells.Science advances · 2025Article
- Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0.FEBS open bio · 2024Article
- Live attenuated-nonpathogenicFrontiers in microbiology · 2024Review
- Review
- Enhancement of Vivid-based photo-activatable Gal4 transcription factor in mammalian cells.Cell structure and function · 2023Article
- In vivo imaging of inflammatory response in cancer research.Inflammation and regeneration · 2023Review
- Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review.Journal of Yeungnam medical science · 2022Article
- Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications.Nature communications · 2022Article
- The emergence of molecular systems neuroscience.Molecular brain · 2022Review
- The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters.Chemical reviews · 2021Review
- Precise optical control of gene expression ineLife · 2021Article
- Mechanisms and cell lineages in lymphatic vascular development.Angiogenesis · 2021Review
- A light way for nuclear cell biologists.Journal of biochemistry · 2021Review
- Photoactivatable Cre knock-in mice for spatiotemporal control of genetic engineering in vivo.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Reverse and Forward Engineering Multicellular Structures with Optogenetics.Current opinion in biomedical engineering · 2020Article
- Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy.Cold Spring Harbor perspectives in medicine · 2020Review
- CreLite: An optogenetically controlled Cre/loxP system using red light.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Techniques allowing precise spatial and temporal control of gene expression in the brain are needed. Herein we describe optogenetic approaches using a photo-activatable Cre recombinase (PA-Cre) to stably modify gene expression in the mouse brain. Blue light illumination for 12 hours via optical fibers activated PA-Cre in the hippocampus, a deep brain structure. Two-photon illumination through a thinned skull window for 100 minutes activated PA-Cre within a sub-millimeter region of cortex. Light activation of PA-Cre may allow permanent gene modification with improved spatiotemporal precision compared to standard methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.