ArticleScientific reports2015
Low doses of ivermectin cause sensory and locomotor disorders in dung beetles.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 138 citations in OpenAlex.
- Ecotoxicity evaluation of thymol in tunneller dung beetles (Coleoptera: Geotrupidae) as a natural alternative to ecotoxic anthelmintics.Ecotoxicology (London, England) · 2026Article
- Efficacy of high doses of ivermectin-clorsulon in cattle on Glossina palpalis gambiensis survival and fecundity: implications for human and animal trypanosomoses control.Parasites & vectors · 2026Article
- Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to ivermectin.Malaria journal · 2025Article
- Tropical Land-Use Change Disrupts Zeta-Diversity Across Taxa.Global change biology · 2025Article
- Ivermectin causes adverse effects on the metabolic rate and thermoregulatory capacity of Dung beetles.Scientific reports · 2025Article
- Biotic interactions in soil and dung shape parasite transmission in temperate ruminant systems: An integrative framework.Ecological applications : a publication of the Ecological Society of America · 2024Review
- Dung removal increases under higher dung beetle functional diversity regardless of grazing intensification.Nature communications · 2023Article
- Population structure of Phanaeus vindex (Coleoptera: Scarabaeidae) in SE Michigan.Journal of insect science (Online) · 2023Article
- Proof-of-concept study for a long-acting formulation of ivermectin injected in cattle as a complementary malaria vector control tool.Parasites & vectors · 2023Article
- Article
- Diseases of Iberian ibex (European journal of wildlife research · 2023Review
- Environmental impacts of mass drug administration programs: exposures, risks, and mitigation of antimicrobial resistance.Infectious diseases of poverty · 2022Review
- Contrasting Volatilomes of Livestock Dung Drive Preference of the Dung BeetleMolecules (Basel, Switzerland) · 2022Article
- Effects of Avermectins on the Environment Based on Its Toxicity to Plants and Soil Invertebrates-a Review.Water, air, and soil pollution · 2022Review
- Effect of macrocyclic lactones on nontarget coprophilic organisms: a review.Parasitology research · 2021Review
- Efficient degradation of ivermectin by newly isolated Aeromonas taiwanensis ZJB-18,044.Biodegradation · 2020Article
- Exposure to low concentrations of pesticide stimulates ecological functioning in the dung beetlePeerJ · 2020Article
- Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer.Biochimica et biophysica acta. Reviews on cancer · 2019Review
- First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences.Scientific reports · 2018Article
- What does not kill it makes it weaker: effects of sub-lethal concentrations of ivermectin on the locomotor activity of Anopheles aquasalis.Parasites & vectors · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ivermectin is a veterinary pharmaceutical generally used to control the ecto- and endoparasites of livestock, but its use has resulted in adverse effects on coprophilous insects, causing population decline and biodiversity loss. There is currently no information regarding the direct effects of ivermectin on dung beetle physiology and behaviour. Here, based on electroantennography and spontaneous muscle force tests, we show sub-lethal disorders caused by ivermectin in sensory and locomotor systems of Scarabaeus cicatricosus, a key dung beetle species in Mediterranean ecosystems. Our findings show that ivermectin decreases the olfactory and locomotor capacity of dung beetles, preventing them from performing basic biological activities. These effects are observed at concentrations lower than those usually measured in the dung of treated livestock. Taking into account that ivermectin acts on both glutamate-gated and GABA-gated chloride ion channels of nerve and muscle cells, we predict that ivermectin's effects at the physiological level could influence many members of the dung pat community. The results indicate that the decline of dung beetle populations could be related to the harmful effects of chemical contamination in the dung.
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Registered trials
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