Evidence map›Paper›PMID 26350588›Full record

ArticleClinical neuroradiology2017

Pharmacokinetic Modeling of Intra-arterial Nimodipine Therapy for Subarachnoid Hemorrhage-Related Cerebral Vasospasm.

F Seker, J Hesser, M A Brockmann, E Neumaier-Probst, C Groden, R Schubert, C Brockmann

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Article in Clinical neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

F SekerDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
J HesserExperimental Radiation Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
M A BrockmannClinic for Diagnostic and Interventional Neuroradiology, University Hospital of the RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
E Neumaier-ProbstDepartment of Neuroradiology, University Medical Center Mannheim, Mannheim, Germany.
C GrodenDepartment of Neuroradiology, University Medical Center Mannheim, Mannheim, Germany.
R SchubertResearch Division Cardiovascular Physiology, Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
C BrockmannClinic for Diagnostic and Interventional Neuroradiology, University Hospital of the RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany. caro.brockmann@gmx.de.
Heidelberg University · DERWTH Aachen University · DEUniversity Medical Centre Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntra-arterial (IA) administration of nimodipine has been shown to be an effective treatment for subarachnoid hemorrhage-related cerebral vasospasm. The concentrations achieved in cerebral arteries during this procedure, though, are unknown. Therefore, there are no clinical studies investigating dose-dependent effects of nimodipine. We aimed at providing a pharmacokinetic model for IA nimodipine therapy for this purpose.

methodsA two-compartment pharmacokinetic model for intravenous nimodipine therapy was modified and used to assess cerebral arterial nimodipine concentration during IA nimodipine infusion into the internal carotid artery (ICA).

resultsAccording to our simulations, continuous IA nimodipine infusion at 2 mg/h and 1 mg/h resulted in steady-state cerebral arterial concentrations of about 200 ng/ml and 100 ng/ml assuming an ICA blood flow of 200 ml/min and a clearance of 70 l/h. About 85 % of the maximal concentration is achieved within the first minute of IA infusion independent on the infusion dose. Within the range of physiological and pharmacokinetic data available in the literature, ICA blood flow has more impact on cerebral arterial concentration than nimodipine clearance.

conclusionThe presented pharmacokinetic model is suitable for estimations of cerebral arterial nimodipine concentration during IA infusion. It may, for instance, assist in dose-dependent analyses of angiographic results.

Indexed as

Models, CardiovascularComputer SimulationHumansInjections, Intra-ArterialMetabolic Clearance RateNimodipineReproducibility of ResultsSensitivity and SpecificitySubarachnoid HemorrhageVasodilator AgentsVasospasm, IntracranialNimodipineVasodilator AgentsAneurysmal subarachnoid hemorrhageCalcium channel antagonistCerebral vasospasmSimulation

Identifiers

PMID26350588
OpenAlexW1620190164

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.