Evidence map›Paper›PMID 26350470›Full record

Trial reportSleep2016

Maxillomandibular Volume Influences the Relationship between Weight Loss and Improvement in Obstructive Sleep Apnea.

Kate Sutherland, Craig L Phillips, Brendon J Yee, Ronald R Grunstein, Peter A Cistulli

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Bidirectional relationships of comorbidity with obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. From CPAP to tailored therapy for obstructive sleep Apnoea.Multidisciplinary respiratory medicine · 2018
    Review
  9. P4 medicine approach to obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kate SutherlandCentre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, Sydney Medical School, University of Sydney, Sydney, Australia.
Craig L PhillipsCentre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, Sydney Medical School, University of Sydney, Sydney, Australia.
Brendon J YeeWoolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
Ronald R GrunsteinWoolcock Institute of Medical Research, University of Sydney, Sydney, Australia.
Peter A CistulliCentre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, Sydney Medical School, University of Sydney, Sydney, Australia.
University of Sydney · AUWoolcock Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesObesity is the major risk factor for OSA; however, weight loss reduces OSA to a variable extent. We aimed to assess whether size of the maxillomandibular skeletal enclosure influences the relationship between weight loss and OSA reduction.

methodsObese males (≥ 30 kg/m2) with moderate-severe OSA (AHI > 15/h) participating in a 6-mo open-label weight loss program had craniofacial computed tomography (CT) scans before and after weight loss. CT scans were analysed using three-dimensional cephalometry. Maxillomandibular volume was calculated from skeletal landmarks on the mandible (condyle, gonion, menton) and maxilla (anterior nasal spine). Multiple regression analysis was used to test for moderating effects of maxillomandibular volume on relationship between changes in weight and apnea-hypopnea index (AHI).

resultsFifty-two men (age 44.3 ± 8.8 y, AHI 42.9 ± 21.3 events/h, body mass index [BMI] 34.0 ± 2.7 kg/m2) had 7.4 ± 4.1% weight loss and 34.1 ± 32.4% AHI reduction at 6 months. BMI reduction modestly predicted AHI change (r2 = 0.17, P = 0.002). The interaction term of maxillomandibular volume and BMI change was a predictor of OSA improvement (P = 0.03), indicating maxillomandibular volume moderates this relationship. Subgroup analyses of patients by small, medium, and large maxillomandibular volume showed a strong correlation between weight loss and OSA improvement only in the small volume group (r = 0.654, P = 0.004). There was no relationship evident in those with large maxillomandibular volume (r = 0.05, P = 0.9).

conclusionMaxillomandibular volume influences the relationship between weight loss and OSA improvement with an effect on AHI more evident in those with a smaller craniofacial skeleton.

Indexed as

AdultAgedBody Mass IndexCephalometryHumansMaleMandibleMaxillaMiddle AgedObesityOrgan SizePolysomnographyRisk FactorsSleep Apnea, ObstructiveWeight Losscomputed tomographycraniofacial structuremaxillomandibular volumeobesityobstructive sleep apneaweight loss

Identifiers

PMID26350470
PMCPMC4678342
OpenAlexW2400326938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.