Evidence map›Paper›PMID 26350306›Full record

ReviewMicrobiology spectrum2015

Candida Biofilms: Development, Architecture, and Resistance.

Jyotsna Chandra, Pranab K Mukherjee

Open access · bronzeAbstract readReview
In one paragraph

Review in Microbiology spectrum, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 157 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. StudyingPharmaceuticals (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Biofilm · 2025
    Article
  11. Genome sequences of six clinical isolates ofMicrobiology resource announcements · 2025
    Article
  12. Control ofFuture microbiology · 2025
    Article
  13. Review
  14. Article
  15. Antibiofilm activity of silver nanoparticles against Candida sp. isolated from the oral cavity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  16. Article
  17. Biofilm Formation in Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jyotsna ChandraCenter for Medical Mycology and Mycology Reference Laboratory, Department of Dermatology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106.
Pranab K MukherjeeCenter for Medical Mycology and Mycology Reference Laboratory, Department of Dermatology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106.
University Hospitals of Cleveland · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Mechanism of antifungal action of Pichia proteinsR01DE024228 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI GHANNOUM, MAHMOUD A · 2014 to 2018
$2.0M
Low-Dose High-Resolution Dental RadiographyR44DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2010 to 2011
$1.1M
Role of extracellular matrix proteins in Candida biofilm formationR21AI074077 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI MUKHERJEE, PRANAB KUMAR · 2009 to 2010
$432k
Biomarkers of Fusarium biofilm formation in vitro and in vivoR21EY021303 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI MUKHERJEE, PRANAB KUMAR · 2011 to 2012
$432k
Low-Dose High-Resolution Dental RadiographyR43DE017846 · NIDCR · DXRAY, INC. · PI HARTSOUGH, NEAL EUGENE · 2007 to 2007
$198k
NEI NIH HHS R21 EY021303NEI NIH HHS R21EY021303NIAID NIH HHS P30 AI036219NIAID NIH HHS R21 AI074077NIAID NIH HHS R21AI074077NIDCR NIH HHS R01 DE024228NIDCR NIH HHS R01DE024228NIDCR NIH HHS R01DE17846NIDCR NIH HHS R43 DE017846NIDCR NIH HHS R44 DE017846
6 · The paper itself

Abstract

Intravascular device-related infections are often associated with biofilms (microbial communities encased within a polysaccharide-rich extracellular matrix) formed by pathogens on the surfaces of these devices. Candida species are the most common fungi isolated from catheter-, denture-, and voice prosthesis-associated infections and also are commonly isolated from contact lens-related infections (e.g., fungal keratitis). These biofilms exhibit decreased susceptibility to most antimicrobial agents, which contributes to the persistence of infection. Recent technological advances have facilitated the development of novel approaches to investigate the formation of biofilms and identify specific markers for biofilms. These studies have provided extensive knowledge of the effect of different variables, including growth time, nutrients, and physiological conditions, on biofilm formation, morphology, and architecture. In this article, we will focus on fungal biofilms (mainly Candida biofilms) and provide an update on the development, architecture, and resistance mechanisms of biofilms.

Indexed as

BiofilmsDrug Resistance, FungalAnimalsAntifungal AgentsCandidaCandidiasisHumansAntifungal Agents

Identifiers

PMID26350306
PMCPMC4566167
OpenAlexW2214801532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.