ArticleAmerican journal of hypertension2016
Prehypertension is Associated With Abnormalities of Cardiac Structure and Function in the Atherosclerosis Risk in Communities Study.
Article in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 1 - Concept, Epidemiology and Primary PreventionArquivos brasileiros de cardiologia · 2016Guideline
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- Stage I hypertension is associated with impaired systolic function by strain imaging compared with prehypertension: A report from the prever study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- Role of left ventricular strain measurements and native T1 and T2 mapping on cardiac magnetic resonance imaging in evaluating early left ventricle myocardial derangement in patients with high normal blood pressure.Journal of cardiovascular and thoracic research · 2026Article
- Electrocardiographic Left Ventricular Mass Trajectories and the Effects of Treatment in Patients at Different Stages of Hypertension.Journal of clinical medicine · 2025Article
- The Interplay of Comorbidities in Chronic Heart Failure: Challenges and Solutions.Current cardiology reviews · 2024Review
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- Social Support: The Effect on Nocturnal Blood Pressure Dipping.International journal of environmental research and public health · 2023Article
- Severity of Nonalcoholic Fatty Liver Disease is Associated With Cardiovascular Outcomes in Patients With Prehypertension or Hypertension: A Community-Based Cohort Study.Frontiers in endocrinology · 2022Article
- Blood Pressure Trajectories for 16 Years and the Development of Left Ventricular Hypertrophy and Increased Left Atrial Size: The Korean Genome and Epidemiology Study.International journal of hypertension · 2022Article
- N6-Adenosine Methylation (mJournal of cardiovascular translational research · 2021Review
- Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021Article
- Vector Flow Mapping Application in Local Cardiac Function in Hypertension Assessment.International journal of general medicine · 2021Article
- Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study.Frontiers in cardiovascular medicine · 2021Article
- The management of prehypertension in young adults.Saudi medical journal · 2020Review
- Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy.Current hypertension reports · 2020Review
- High Blood Pressure and Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Article
- Observational
- The influence of prehypertension, controlled and uncontrolled hypertension on left ventricular diastolic function and structure in the general Korean population.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundPrehypertension (blood pressure (BP) of 120-139 mm Hg systolic and/or 80-89 mm Hg diastolic) is highly prevalent and is associated with increased cardiovascular risk. Our goal was to investigate the extent to which prehypertension is associated with end-organ alterations in cardiac structure and function in a large biracial cohort of older men and women.
methodsWe studied 4,871 participants of the Atherosclerosis Risk in Communities (ARIC) study who attended visit 5 (2011-2013) and underwent two-dimensional echocardiography while free of prevalent coronary heart disease or heart failure. We categorized participants into 3 groups: optimal BP (BP <120 mm Hg and <80 mm Hg) (n = 402), prehypertension (n = 537), and hypertension (n = 3,932).
resultsIndividuals with prehypertension (75±5 years) had higher left ventricular (LV) mass index and wall thickness, and higher prevalence of abnormal LV geometry than those with optimal BP (74±5 years), but lower than those with frank hypertension (76±5 years). In addition, participants with prehypertension had impairment of diastolic parameters (E/A, E' and E/E'), and had higher prevalence of mild and moderate-severe diastolic dysfunction compared to those with optimal BP, but no differences in systolic parameters. These differences in cardiac structure and function remained significant after adjusting for important clinical covariates.
conclusionIn the ARIC cohort at visit 5, prehypertension was associated with increased LV remodeling and impaired diastolic function, but not systolic function, suggesting that even mildly elevated BP within the normal range is associated with cardiac end-organ damage.
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