ArticleFood & nutrition research2015
Protective effects of Carissa opaca fruits against CCl4-induced oxidative kidney lipid peroxidation and trauma in rat.
Article in Food & nutrition research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
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- Article
- Chemical characterization and evaluation of the nephroprotective potential ofSaudi journal of biological sciences · 2022Article
- The Preventive Effects of Fermented and Germinated Foxtail Millet Whole Grain on Kidney Damage in a Diabetic Mouse Model.Frontiers in nutrition · 2022Article
- Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CClBMC complementary medicine and therapies · 2021Article
- Pilea umbrosa ameliorate CClEnvironmental health and preventive medicine · 2020Article
- Efficacy of two actinomycete extracts in the amelioration of carbon tetrachloride-induced oxidative stress and nephrotoxicity in experimental rats.Environmental science and pollution research international · 2019Article
- Protective effects of Monotheca buxifolia fruit on renal toxicity induced by CCl4 in rats.BMC complementary and alternative medicine · 2016Article
- Proficiencies of Artemisia scoparia against CCl4 induced DNA damages and renal toxicity in rat.BMC complementary and alternative medicine · 2016Article
- Renoprotective effects of the methanolic extract ofAvicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbon tetrachloride (CCl4) is a potent nephrotoxin, as it causes acute as well as chronic toxicity in kidneys. Therefore, this study was carried out to assess the pharmacological potential of different fractions of Carissa opaca fruits on CCl4-induced oxidative trauma in the kidney.
methodsThe parameters studied in this respect were the kidney function tests viz, serum profile, urine profile, genotoxicity, characteristic morphological findings, and antioxidant enzymatic level of kidneys.
resultThe protective effects of various fractions of C. opaca fruits against CCl4 administration were reviewed by rat renal function alterations. Chronic toxicity caused by 8-week treatment of CCl4 to the rats significantly decreased the pH level, activities of antioxidant enzymes, and glutathione contents, whereas a significant increase was found in the case of specific gravity, red blood cells, white blood cells, level of urea, and lipid peroxidation in comparison to control group. Administration of various fractions of C. opaca fruit with CCl4 showed protective ability against CCl4 intoxication by restoring the urine profile, activities of antioxidant enzymes, and lipid peroxidation in rat. CCl4 induction in rats also caused DNA fragmentation and glomerular atrophy by means of dilation, disappearance of Bowmen's space, congestion in the capillary loops, dilation in renal tubules, and foamy look of epithelial cells of tubular region, which were restored by co-admiration of various fractions of C. opaca.
conclusionResults revealed that the methanolic fractions of C. opaca are the most potent and helpful in kidney trauma.
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