Evidence map›Paper›PMID 26350141›Full record

ArticleLeukemia research2015

BRAF

Yo-Ting Tsai, Gerard Lozanski, Amy Lehman, Ellen J Sass, Erin Hertlein, Santosh B Salunke, Ching-Shih Chen, Michael R Grever, John C Byrd, David M Lucas

Abstract read
In one paragraph

Article in Leukemia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. BRAFBlood advances · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yo-Ting TsaiDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Gerard LozanskiDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Amy LehmanCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Ellen J SassDepartment of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA.
Erin HertleinDepartment of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA.
Santosh B SalunkeDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Ching-Shih ChenDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
Michael R GreverDepartment of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA.
John C ByrdDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA.
David M LucasDivision of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, College of Medicine; The Ohio State University, Columbus, OH, USA. Electronic address: david.lucas@osumc.edu.
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
SPORE Leukemia Tissue BankP50CA140158 · NCI · OHIO STATE UNIVERSITY · PI MARCUCCI, GUIDO · 2009 to 2013
$11.2M
NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA140158
6 · The paper itself

Abstract

A subset of patients with chronic lymphocytic leukemia (CLL) and nearly all patients with classic hairy cell leukemia (HCL) harbor somatic BRAF activating mutations. However, the pathological role of activated BRAF in B-cell leukemia development and progression remains unclear. In addition, although HCL patients respond well to the BRAF

Indexed as

ABCB1B-cellBRAFLeukemiaLymphomaP-glycoproteinVemurafenib

Identifiers

PMID26350141
PMCPMC4779435
OpenAlexW2254996017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.