Evidence map›Paper›PMID 26350056›Full record

ArticlePathology oncology research : POR2016

Evaluation of PAX8 Expression and Its Potential Diagnostic and Prognostic Value in Renal and Extra-Renal Ewing Sarcomas/PNETs.

Michael Markow, Marilyn M Bui, Hui-Yi Lin, Mark Lloyd, Wade J Sexton, Jasreman Dhillon

Abstract readEvaluation Study
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In one paragraph

Article in Pathology oncology research : POR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael MarkowDepartment of Pathology and Cell Biology, University of South Florida, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Marilyn M BuiDepartment of Pathology and Cell Biology, University of South Florida, 12902 Magnolia Drive, Tampa, FL, 33612, USA.
Hui-Yi LinDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Mark LloydAnalytic Microscopy Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Wade J SextonDepartment of Genitourinary Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jasreman DhillonDepartment of Pathology and Cell Biology, University of South Florida, 12902 Magnolia Drive, Tampa, FL, 33612, USA. jasreman.dhillon@moffitt.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PAX8 is a transcription factor involved in the regulation of organogenesis of the thyroid gland, kidney, and Müllerian system. It is commonly expressed in epithelial tumors of thyroid and parathyroid glands, kidney, thymus, and female genital tract. PAX8 is increasingly used in the establishment of tissue of origin in carcinomas and has recently been identified in a subset of small blue round cell tumors including Ewing sarcomas/PNETs. However, it is unclear if this association in ES/PNETs is due to renal origin or is PNET specific. In this study we investigated the PAX8 staining pattern of primary renal and extra-renal ES/PNETs to explore its potential diagnostic and prognostic role. A tissue microarray (TMA) of 22 cases of extra-renal Ewing/PNETs and two separate cases of primary renal PNET whole slide sections were immunohistochemically stained with rabbit polyclonal PAX8 antibody. PAX8 was positive in 2 of 2 primary renal PNETs and in 14 (64 %) cases of the extra renal PNETs. The association between PAX8 immunoreactivity and Ewing/PNET was identified in both primary renal and extra-renal Ewing/PNETs for the first time. Further studies are warranted to verify these findings and to shed light in the tumorigenesis of Ewing/PNET. However, PAX8 is not useful in establishing a diagnosis of Ewing/PNET due to its presence in different tumors like carcinomas, lymphomas and sarcomas. PAX8 does not seem to have prognostic value.

Indexed as

AdolescentAdultAgedBiomarkers, TumorBone NeoplasmsFemaleFollow-Up StudiesHumansImmunoenzyme TechniquesKidney NeoplasmsMaleMiddle AgedNeoplasm StagingNeuroectodermal Tumors, PrimitivePaired Box Transcription FactorsPAX8 Transcription FactorBiomarkers, TumorPaired Box Transcription FactorsPAX8 protein, humanPAX8 Transcription FactorPAX8PNETRenal PNET

Identifiers

PMID26350056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.