Evidence map›Paper›PMID 26349915›Full record

ArticleInfection2016

Heel quantitative ultrasound in HIV-infected patients: a cross-sectional study.

Marilia Rita Pinzone, Daniela Castronuovo, Adriana Di Gregorio, Benedetto Maurizio Celesia, Maria Gussio, Marco Borderi, Paolo Maggi, Carmen Rita Santoro, Giordano Madeddu, Bruno Cacopardo and 1 more

Registry-linked trialAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05125458 (Interrelationships Among Inflammation, Physical Symptoms, Mental Symptoms and Quality of Life in Subjects With Chronic Inflammatory Physical Diseases.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05125458 completednot on this mapstarted 2021, after this paper: background citation

Interrelationships Among Inflammation, Physical Symptoms, Mental Symptoms and Quality of Life in Subjects With Chronic Inflammatory Physical Diseases.

TypeobservationalSponsorUniversity of Campania Luigi VanvitelliRan2021 to 2022Enrolled93ConditionsChronic Infectious Disease, Chronic Skin Disease, Mental Disorders, Psoriasis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. HIV Infection and Bone Abnormalities.The open orthopaedics journal · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Marilia Rita PinzoneDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Daniela CastronuovoDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Adriana Di GregorioDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Benedetto Maurizio CelesiaDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Maria GussioDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Marco BorderiInfectious Diseases Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Paolo MaggiInstitute of Infectious Diseases, Policlinico-University of Bari, Bari, Italy.
Carmen Rita SantoroInstitute of Infectious Diseases, Policlinico-University of Bari, Bari, Italy.
Giordano MadedduUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.
Bruno CacopardoDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy.
Giuseppe NunnariDivision of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Via Palermo 636, 95100, Catania, Italy. gnunnari@hotmail.com.
Ospedale Garibaldi · ITUniversity of Catania · ITUniversity of Bari Aldo Moro · ITUniversity of Bologna · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHIV infection has been associated with increased risk of osteoporosis and fragility fractures. Dual-energy X-ray absorptiometry (DXA) is the reference standard to assess bone mineral density (BMD); however, it is not easily accessible in several settings. Heel Quantitative ultrasound (QUS) is a radiation-free, easy-to-perform technique, which may help reducing the need for DXA.

methodsIn this cross-sectional study, we used heel QUS (Hologic Sahara(®)) to assess bone status in a cohort of HIV-infected patients. A QUS stiffness index (QUI) threshold >83 was used to identify patients with a low likelihood of osteoporosis. Moreover, we compared QUS results with those of 36 sex- and age-matched HIV-negative controls.

results244 HIV-positive patients were enrolled. Median heel QUI value was 83 (73-96) vs. 93 (IQR 84-104) in the control group (p = 0.04). 110 patients (45 %) had a QUI value ≤83. Risk factors for low QUI values were age (OR 1.04 per year, 95 % CI 1.01-1.07, p = 0.004), current use of protease inhibitors (OR 1.85, CI 1.03-3.35, p = 0.039), current use of tenofovir (OR 2.28, CI 1.22-4.27, p = 0.009) and the number of risk factors for secondary osteoporosis (OR 1.46, CI 1.09-1.95, p = 0.01). Of note, QUI values were significantly correlated with FRAX score (r = -0.22, p = 0.004). According to EACS guidelines, 45 % of patients had risk factors for osteoporosis which make them eligible for DXA. By using QUS, we may avoid DXA in around half of them.

conclusionsAs HIV-positive patients are living longer, the prevalence of osteoporosis is expected to increase over time. Appropriate screening, prevention and treatment are crucial to preserve bone health in this population. The use of screening techniques, such as heel QUS, may help reducing the need for DXA. Further studies are needed to define the diagnostic accuracy of this promising technique in the setting of HIV.

Indexed as

AdultCross-Sectional StudiesFemaleHeelHIV InfectionsHumansMaleMass ScreeningMiddle AgedOsteoporosisUltrasonographyBMDDXAHeelHIVOsteoporosisQUS

Identifiers

PMID26349915
OpenAlexW1659867598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.