Evidence map›Paper›PMID 26349843›Full record

Trial reportThe British journal of surgery2015

Randomized clinical trial of topical tranexamic acid after reduction mammoplasty.

K Ausen, R Fossmark, O Spigset, H Pleym

8 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 49 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 7 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01964781 phase4completednot on this map

The Effect of Topical Administration of Tranexamic Acid, Adrenaline and Bupivacain on Postoperative Bleeding and Pain in Patients Undergoing Breast Surgery. A Four-armed Placebo-controlled Double Blinded Randomized Study

TypeinterventionalSponsorSt. Olavs HospitalRan2013 to 2014Enrolled30ConditionsPain, Postoperative, Postoperative HemorrhageArmsTranexamic Acid, Bupivacaine, Adrenaline, tranexamic acid plus saline, saline
NCT02627560 phase4completednot on this mapstarted 2016, after this paper: background citation

The Effect of Topical Administration of Tranexamic Acid on Postoperative Bleeding and Seroma Formation in Patients Undergoing Mastectomy: A Prospective Placebo-controlled Double Blinded Randomized Study

TypeinterventionalSponsorSt. Olavs HospitalRan2016 to 2018Enrolled202ConditionsPostoperative Hemorrhage, Breast Neoplasms, SeromaArmsTranexamic Acid, saline
NCT03738527 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Pilot RCT: Use of Tranexamic Acid (TXA) in Post Mastectomy Patients for Seroma and Hematoma Prevention

TypeinterventionalSponsorHamilton Health Sciences CorporationRan2019 to 2022Enrolled100ConditionsSeroma Complicating A Procedure, Hematoma Postoperative, Breast CancerArmsTranexamic Acid 100mg/mL, 20mL topical, Normal Saline Flush, 0.9%, 20mL topical
NCT04902950 phase4terminatednot on this mapstarted 2020, after this paper: background citation

Role of Tranexamic Acid (TXA) in the Reduction of Post-operative Hematoma and Seroma in Patients Undergoing Panniculectomy or Abdominoplasty, a Pilot Study.

TypeinterventionalSponsorThe Reading Hospital and Medical CenterRan2020 to 2021Enrolled9ConditionsPanniculectomy, AbdominoplastyArmsTranexamic acid, Saline
NCT04947514 phase4completednot on this mapstarted 2021, after this paper: background citation

Use of TRanEXamic Acid in Reduction Mammoplasty (TREX-ARM): a Double-blinded Randomized Controlled Trial

TypeinterventionalSponsorMontefiore Medical CenterRan2021 to 2022Enrolled98ConditionsHematoma Postoperative, Venous ThromboembolismArmsTranexamic acid, Placebo (topical saline)
NCT04951128 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery

TypeinterventionalSponsorConsultants in Ophthalmic and Facial Plastics SurgeryRan2021 to 2022Enrolled50ConditionsEdema, Ecchymosis, EyelidArmsTranexamic acid injection, Local anesthetic control
NCT05554211 phase2withdrawnnot on this mapstarted 2022, after this paper: background citation

Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage

TypeinterventionalSponsorNorthwestern UniversityRan2022 to 2024Enrolled0ConditionsBreast Cancer, BRCA MutationArmsTranexamic acid, Normal saline
NCT07131592 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Tranexamic Acid on Drainage Volume and Time to Drain Removal in Reduction Mammaplasty Patients

TypeinterventionalSponsorMassachusetts General HospitalRan2025 to 2027Enrolled160ConditionsDrain Output After Breast Reduction Surgery, Breast ReductionsArmsIV TXA, Topical TXA, Topical saline
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 7 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

K AusenDepartments of Plastic and Reconstructive Surgery, St Olav's University Hospital, Trondheim, Norway.
R FossmarkDepartments of Internal Medicine, St Olav's University Hospital, Trondheim, Norway.
O SpigsetDepartments of Clinical Pharmacology, St Olav's University Hospital, Trondheim, Norway.
H PleymClinic of Anaesthesia and Intensive Care, St Olav's University Hospital, Trondheim, Norway.
St Olav's University Hospital · NONorwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe antifibrinolytic drug tranexamic acid is currently being rediscovered for both trauma and major surgery. Intravenous administration reduces the need for blood transfusion and blood loss by about one-third, but routine administration in surgery is not yet advocated owing to concerns regarding thromboembolic events. The aim of this study was to investigate whether topical application of tranexamic acid to a wound surface reduces postoperative bleeding.

methodsThis was a randomized double-blind placebo-controlled trial on 30 consecutive women undergoing bilateral reduction mammoplasty. On one side the wound surfaces were moistened with 25 mg/ml tranexamic acid before closure, and placebo (saline) was used on the other side. Drain fluid production was measured for 24 h after surgery, and pain was measured after 3 and 24 h. Postoperative complications including infection, seroma, rebleeding and suture reactions were recorded.

resultsTopical application of tranexamic acid to the wound surface after reduction mammoplasty reduced drain fluid production by 39 per cent (median 12·5 (range 0-44) versus 20·5 (0-100) ml; P = 0·038). Adverse effects were not observed. There were no significant differences in postoperative pain scores or complications.

conclusionTopical application of dilute tranexamic acid reduced bleeding in this model. The study adds to the evidence that this simple procedure may reduce wound bleeding after surgery. REGISTRATION NUMBER: NCT01964781 ( http://www.clinicaltrials.gov).

Indexed as

MammaplastyAdministration, TopicalAdolescentAdultAgedAntifibrinolytic AgentsDouble-Blind MethodFemaleFollow-Up StudiesHumansMiddle AgedPostoperative HemorrhageTranexamic AcidTreatment OutcomeYoung AdultAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID26349843
PMCPMC4600231
OpenAlexW1889186786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.