Evidence map›Paper›PMID 26349637›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2015

Interfacing Inorganic Nanowire Arrays and Living Cells for Cellular Function Analysis.

Minsuk Kwak, Lin Han, Jonathan J Chen, Rong Fan

Abstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Semi-Implantable Bioelectronics.Nano-micro letters · 2022
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization.Annual review of analytical chemistry (Palo Alto, Calif.) · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Minsuk KwakDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.
Lin HanDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.
Jonathan J ChenDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.

Funding

The Cell-Of-Origin of Human CancersU54CA143798 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MICHOR, FRANZISKA · 2009 to 2014
$11.2M
Project 3: Single Cell Measures of Intratumor Diversity for Optimal Breast Cancer TherapyU54CA193461 · NCI · DANA-FARBER CANCER INST · PI HOLLAND, ERIC C. · 2015 to 2020
$11.2M
Integrated Microchips for Informative Diagnosis of Cancer-immune InteractionsR00CA136759 · NCI · YALE UNIVERSITY · PI FAN, RONG · 2010 to 2012
$707k
Integrated Microchips for Informative Diagnosis of Cancer-immune InteractionsK99CA136759 · NCI · YALE UNIVERSITY · PI FAN, RONG · 2009 to 2009
$89k
NCI NIH HHS K99 CA136759NCI NIH HHS R00 CA136759NCI NIH HHS U54 CA143798NCI NIH HHS U54 CA193461
6 · The paper itself

Abstract

Inorganic nanowires are among the most attractive functional materials, which have emerged in the past two decades. They have demonstrated applications in information technology and energy conversion, but their utility in biological or biomedical research remains relatively under-explored. Although nanowire-based sensors have been frequently reported for biomolecular detection, interfacing nanowire arrays and living mammalian cells for the direct analysis of cellular functions is a very recent endeavor. Cell-penetrating nanowires enabled effective delivery of biomolecules, electrical and optical stimulation and recording of intracellular signals over a long period of time. Non-penetrating, high-density nanowire arrays display rich interactions between the nanostructured substrate and the micro/nanoscale features of cell surfaces. Such interactions enable efficient capture of rare cells including circulating tumor cells and trafficking leukocytes from complex biospecimens. It also serves as a platform for probing cell traction force and neuronal guidance. The most recent advances in the field that exploits nanowire arrays (both penetrating and non-penetrating) to perform rapid analysis of cellular functions potentially for disease diagnosis and monitoring are reviewed.

Indexed as

Cell Physiological PhenomenaMicroarray AnalysisAnimalsCell AdhesionCell CommunicationEukaryotic CellsHumansNanowiresSurface PropertiesTissue Scaffoldscell-substrate interactions, cellular function analysisintracellular deliverynanowire arraysrare cell analysis

Identifiers

PMID26349637
PMCPMC4676807

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.