Evidence map›Paper›PMID 26349488›Full record

ArticleOrganic & biomolecular chemistry2015

Synthesis of aza and carbocyclic β-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted β- and aza-β-carboline specificity.

V V N Phani Babu Tiruveedhula, Kashi Reddy Methuku, Jeffrey R Deschamps, James M Cook

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Looking back at a life in sleep research-and some thoughts for the future.Sleep advances : a journal of the Sleep Research Society · 2022
    Article
  2. Effects of the benzodiazepine GABADrug and alcohol dependence · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

V V N Phani Babu TiruveedhulaDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. capncook@uwm.edu.
Kashi Reddy MethukuDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. capncook@uwm.edu.
Jeffrey R DeschampsCenter for Bimolecular Science and Engineering, Naval Research Laboratory, Code 6930, Washington, D. C. 20375, USA.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. capncook@uwm.edu.
University of Wisconsin–Milwaukee · USUnited States Naval Research Laboratory · US

Funding

GABAa receptor subtype mechanisms in nonhuman primatesR01AA016179 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2006 to 2016
$3.2M
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NHLBI NIH HHS R01 HL118561NIAAA NIH HHS 7R01AA-016179NIAAA NIH HHS R01 AA016179NIMH NIH HHS 1R01MH096463-01A1NIMH NIH HHS R01 MH096463NINDS NIH HHS 5R01NS076517-03NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

A novel two step protocol was developed to gain regiospecific access to 3-substituted β- and aza-β-carbolines, 3-PBC (1), 3-ISOPBC (2), βCCt (3), 6-aza-3-PBC (4) and 6-aza-3-ISOPBC (5). These β-carbolines (1-3) are potential clinical agents to reduce alcohol self-administration, especially 3-ISOPBC·HCl (2·HCl) which appears to be a potent anti-alcohol agent active against binge drinking in a rat model of maternally deprived (MD) rats. The method consists of two consecutive palladium-catalyzed reactions: a Buchwald-Hartwig amination followed by an intramolecular Heck-type cyclization in high yield.

Indexed as

AlcoholismAnimalsAza CompoundsBinge DrinkingCarbolinesCatalysisModels, MolecularPalladiumRatsStereoisomerismAza CompoundsCarbolinesPalladium

Identifiers

PMID26349488
PMCPMC4704088
OpenAlexW1797101491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.