SynthesisPloS one2015
Reliability of Intra-Retinal Layer Thickness Estimates.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The APOSTEL recommendations for reporting quantitative optical coherence tomography studies.Neurology · 2016Guideline
- Reliability of Macular Ganglion Cell-Inner Plexiform Layer Thickness Measurements Across Scan Protocols in Spectral-Domain Optical Coherence Tomography.Journal of clinical medicine · 2026Article
- Retinal imaging and tissue analysis for frontotemporal degeneration: recent advances and challenges for biomarker development.Journal of neurology, neurosurgery, and psychiatry · 2025Review
- Retinal neuronal loss and progression independent of relapse activity in multiple sclerosis.Journal of neurology · 2025Article
- The Inner Nuclear Layer in Pediatric Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Keeping an eye on Parkinson's disease: color vision and outer retinal thickness as simple and non-invasive biomarkers.Journal of neurology · 2025Review
- The Effects of Disease-Modifying Therapies on Optic Nerve Degeneration in Multiple Sclerosis.European journal of neurology · 2025Review
- Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer ThicknessNeurology(R) neuroimmunology & neuroinflammation · 2024Article
- Patterns of Structural Changes in the Fundus Measured by Optical Coherence Tomography Angiography as Potential Markers of Acute Mountain Sickness.Translational vision science & technology · 2023Article
- Variability of Visual Recovery with Time in Epiretinal Membrane Surgery: A Predictive Analysis Based on Retinal Layer OCT Thickness Changes.Journal of clinical medicine · 2023Article
- The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis.Neurology · 2022Article
- Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- In vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility.Journal of visualized experiments : JoVE · 2022Article
- Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology.PloS one · 2022Article
- Retinal Optical Coherence Tomography in Neuromyelitis Optica.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Reply to Letter to the Editor re: "The Relationship Between Keratoconus Stage and the Thickness of the Retinal Layers"Turkish journal of ophthalmology · 2021Article
- Increased Serum Neurofilament Light and Thin Ganglion Cell-Inner Plexiform Layer Are Additive Risk Factors for Disease Activity in Early Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies.Neurology · 2021Article
- Artificial intelligence extension of the OSCAR-IB criteria.Annals of clinical and translational neurology · 2021Review
- The Relationship Between Keratoconus Stage and the Thickness of the Retinal LayersTurkish journal of ophthalmology · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMeasurement of intra-retinal layer thickness using optical coherence tomography (OCT) has become increasingly prominent in multiple sclerosis (MS) research. Nevertheless, the approaches used for determining the mean layer thicknesses vary greatly. Insufficient data exist on the reliability of different thickness estimates, which is crucial for their application in clinical studies. This study addresses this lack by evaluating the repeatability of different thickness estimates.
methodsStudies that used intra-retinal layer segmentation of macular OCT scans in patients with MS were retrieved from PubMed. To investigate the repeatability of previously applied layer estimation approaches, we generated datasets of repeating measurements of 15 healthy subjects and 13 multiple sclerosis patients using two OCT devices (Cirrus HD-OCT and Spectralis SD-OCT). We calculated each thickness estimate in each repeated session and analyzed repeatability using intra-class correlation coefficients and coefficients of repeatability.
resultsWe identified 27 articles, eleven of them used the Spectralis SD-OCT, nine Cirrus HD-OCT, two studies used both devices and two studies applied RTVue-100. Topcon OCT-1000, Stratus OCT and a research device were used in one study each. In the studies that used the Spectralis, ten different thickness estimates were identified, while thickness estimates of the Cirrus OCT were based on two different scan settings. In the simulation dataset, thickness estimates averaging larger areas showed an excellent repeatability for all retinal layers except the outer plexiform layer (OPL).
conclusionsGiven the good reliability, the thickness estimate of the 6mm-diameter area around the fovea should be favored when OCT is used in clinical research. Assessment of the OPL was weak in general and needs further investigation before OPL thickness can be used as a reliable parameter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.