ReviewHistopathology2016
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Review in Histopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Breast Fibromatosis: Clinical and Pathological Insights From Two Case Reports.Clinical case reports · 2026Article
- Pleomorphic Adenoma in the Setting of Triple-Negative Breast Cancer: A Case Report.Clinical case reports · 2025Article
- Molecular pathology in breast disease: diagnostic, prognostic, and therapeutic tools.Virchows Archiv : an international journal of pathology · 2024Review
- Invasive papillary carcinoma of the breast.Frontiers in oncology · 2024Review
- Article
- Papillary lesions of the breast.Virchows Archiv : an international journal of pathology · 2022Review
- AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2021.Breast care (Basel, Switzerland) · 2021Review
- Article
- Rare Breast Cancer Subtypes.Current oncology reports · 2021Review
- A Case Series of Breast Metastases from Different Extramammary Malignancies and Their Literature Review.Case reports in radiology · 2019Article
- Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis.Case reports in pathology · 2018Article
- Neoplasm of uncertain behaviour of the breast-a retrospective study in a breast unit.Ecancermedicalscience · 2018Article
- The Spectrum of Triple-Negative Breast Disease: High- and Low-Grade Lesions.The American journal of pathology · 2017Review
- Desmoid-type fibromatosis of the breast: A report of 2 cases.Oncology letters · 2017Article
- Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- A case of matrix-producing metaplastic carcinoma of the breast exhibiting similarities to pleomorphic adenoma on fine-needle aspiration cytology.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 14 institutions in 11 countries.
Funding
Abstract
Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include biologically invasive malignant lesions associated with uncertain metastatic potential, such as low-grade adenosquamous carcinoma, low-grade fibromatosis-like spindle cell carcinoma and encapsulated papillary carcinoma. Other lesions of uncertain malignant nature remain, such as mammary cylindroma, atypical microglandular adenosis, mammary pleomorphic adenoma and infiltrating epitheliosis. The concept of categories of (1) breast lesions of uncertain malignant nature and (2) breast lesions of limited metastatic potential are proposed with details of which histological entities could be included in each category, and their management implications are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.