ArticleThe American journal of pathology2015
Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.
Article in The American journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- From defense to disease: the multifaceted role of lymphatics during infection.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Insights to Ang/Tie signaling pathway: another rosy dawn for treating retinal and choroidal vascular diseases.Journal of translational medicine · 2024Review
- Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.EMBO reports · 2024Article
- Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Research advances in airway remodeling in asthma: a narrative review.Annals of translational medicine · 2022Review
- The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer.International journal of molecular sciences · 2020Review
- Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling.International journal of molecular sciences · 2020Article
- Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.The Journal of clinical investigation · 2020Article
- Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging.Journal of hepatocellular carcinoma · 2020Review
- Insights From Dynamic Neuro-Immune Imaging on Murine Immune Responses to CNS Damage.Frontiers in neuroscience · 2019Review
- Biomimetic post-capillary venule expansions for leukocyte adhesion studies.Scientific reports · 2018Article
- Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.Nature medicine · 2017Article
- Therapeutic targeting of the angiopoietin-TIE pathway.Nature reviews. Drug discovery · 2017Review
- Infection-Induced Vascular Permeability Aids Mycobacterial Growth.The Journal of infectious diseases · 2017Article
- Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems.Clinical science (London, England : 1979) · 2017Review
- Tie1 controls angiopoietin function in vascular remodeling and inflammation.The Journal of clinical investigation · 2016Article
- Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.The Journal of clinical investigation · 2016Article
- Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Remodeling of blood vessels and lymphatics are prominent features of sustained inflammation. Angiopoietin-2 (Ang2)/Tie2 receptor signaling and tumor necrosis factor-α (TNF)/TNF receptor signaling are known to contribute to these changes in airway inflammation after Mycoplasma pulmonis infection in mice. We determined whether Ang2 and TNF are both essential for the remodeling on blood vessels and lymphatics, and thereby influence the actions of one another. Their respective contributions to the initial stage of vascular remodeling and sprouting lymphangiogenesis were examined by comparing the effects of function-blocking antibodies to Ang2 or TNF, given individually or together during the first week after infection. As indices of efficacy, vascular enlargement, endothelial leakiness, venular marker expression, pericyte changes, and lymphatic vessel sprouting were assessed. Inhibition of Ang2 or TNF alone reduced the remodeling of blood vessels and lymphatics, but inhibition of both together completely prevented these changes. Genome-wide analysis of changes in gene expression revealed synergistic actions of the antibody combination over a broad range of genes and signaling pathways involved in inflammatory responses. These findings demonstrate that Ang2 and TNF are essential and synergistic drivers of remodeling of blood vessels and lymphatics during the initial stage of inflammation after infection. Inhibition of Ang2 and TNF together results in widespread suppression of the inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.