ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2016
Socioeconomic modifiers of genetic and environmental influences on body mass index in adult twins.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Socioeconomic position, genetic susceptibility, and epigenetic profiles in obesity across the life course: a systematic review.International journal of obesity (2005) · 2026Pooled it
- Clusters of parental socioeconomic status in early childhood and inherited risk for cerebrovascular disease until mid-life-Northern Finland Birth Cohort 1966.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Socio-economic differences in body mass index: the contribution of genetic factors.International journal of obesity (2005) · 2024Article
- Does neighbourhood deprivation influence low back pain and arthritis: An empirical study using multilevel twin design.PloS one · 2024Article
- Modification of TSH-related genetic effects by indicators of socioeconomic position.Endocrine connections · 2023Article
- Parental resources and heritability as factors shaping children's health. An analysis of twins' self-rated health using TwinLife.Frontiers in sociology · 2023Article
- Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents.International journal of obesity (2005) · 2021Article
- Gene-Environment Interplay Between Physical Exercise and Fitness and Depression Symptomatology.Behavior genetics · 2020Article
- The obesity epidemic - Nature via nurture: A narrative review of high-income countries.SAGE open medicine · 2020Review
- Cohort Profile: TWINS study of environment, lifestyle behaviours and health.International journal of epidemiology · 2019Article
- Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.Obesity (Silver Spring, Md.) · 2019Article
- Dermatoglyphical impressions are different between children and adolescents with normal weight, overweight and obesity: a cross-sectional study.F1000Research · 2019Article
- SES-of-Origin and BMI in Youth: Comparing Germany and Minnesota.Behavior genetics · 2019Article
- Variation in the Heritability of Child Body Mass Index by Obesogenic Home Environment.JAMA pediatrics · 2018Article
- Attained SES as a moderator of adult cognitive performance: Testing gene-environment interaction in various cognitive domains.Developmental psychology · 2018Article
- Education as a moderator of genetic risk for higher body mass index: prospective cohort study from childhood to adulthood.International journal of obesity (2005) · 2018Article
- Fat mass and obesity-associated (FTO) rs9939609 polymorphism modifies the relationship between body mass index and affective symptoms through the life course: a prospective birth cohort study.Translational psychiatry · 2018Article
- Article
- Review
- Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity.Current obesity reports · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveIndividual measures of socioeconomic status (SES) suppress genetic variance in body mass index (BMI). Our objective was to examine the influence of both individual-level (i.e., educational attainment, household income) and macrolevel (i.e., neighborhood socioeconomic advantage) SES indicators on genetic contributions to BMI.
methodThe study used education level data from 4,162 monozygotic (MZ) and 1,900 dizygotic (DZ) same-sex twin pairs (64% female), income level data from 3,498 MZ and 1,534 DZ pairs (65% female), and neighborhood-level socioeconomic deprivation data from 2,327 MZ and 948 DZ pairs (65% female). Covariates included age (M = 40.4 ± 17.5 years), sex, and ethnicity. The cotwin control model was used to evaluate the mechanisms through which SES influences BMI (e.g., through genetic vs. environmental pathways), and a gene-by-environment interaction model was used to test whether residual variance in BMI, after controlling for the main effects of SES, was moderated by socioeconomic measures.
resultsSES significantly predicted BMI. The association was noncausal, however, and instead was driven primarily through a common underlying genetic background that tended to grow less influential as SES increased. After controlling for the main effect of SES, both genetic and nonshared environmental variance decreased with increasing SES.
conclusionsThe impact of individual and macrolevel SES on BMI extends beyond its main effects. The influence of genes on BMI is moderated by individual and macrolevel measures of SES, such that when SES is higher, genetic factors become less influential.
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