ArticlePloS one2015
A Lead ANRIL Polymorphism Is Associated with Elevated CRP Levels in Periodontitis: A Pilot Case-Control Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Decoding the periodontitis-coronary artery disease axis through biomarker profiling: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- The roles of ANRIL polymorphisms in periodontitis: a systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis.Bioscience reports · 2018Pooled it
- Associations of the Expression Levels and Risk Variants of CDKN2B-AS1 Long Noncoding RNA With the Susceptibility and Progression of Prostate Cancer.Journal of cellular and molecular medicine · 2024Article
- MicroRNAs: The Missing Link between Hypertension and Periodontitis?International journal of molecular sciences · 2024Review
- Dysregulation of LncRNAs ANRIL, MALAT1, and LINC00305 in Coronary Slow Flow Patients: Implications for Inflammation and Endothelial Dysfunction.International journal of molecular and cellular medicine · 2024Article
- Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer.Journal of cellular and molecular medicine · 2023Article
- Bibliometric research on analysis of links between periodontitis and cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Article
- A novel lncRNA-mediated epigenetic regulatory mechanism in periodontitis.International journal of biological sciences · 2023Article
- Emerging role of epigenetic regulations in periodontitis: a literature review.American journal of translational research · 2022Review
- Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population.Clinical oral investigations · 2021Article
- Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives.Clinical epigenetics · 2021Review
- Multiple Non-coding ANRIL Transcripts Are Associated with Risk of Coronary Artery Disease: a Promising Circulating Biomarker.Journal of cardiovascular translational research · 2021Article
- Periodontitis and Hypertension: Is the Association Causal?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- Approaching Sex Differences in Cardiovascular Non-Coding RNA Research.International journal of molecular sciences · 2020Review
- The role of inflammation and genetics in periodontal disease.Periodontology 2000 · 2020Review
- The lncRNANon-coding RNA research · 2020Article
- Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review.Medicina (Kaunas, Lithuania) · 2020Article
- Periodontitis and cardiovascular diseases: Consensus report.Journal of clinical periodontology · 2020Review
- Periodontitis and Cardiovascular Diseases. Consensus Report.Global heart · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated high sensitive C-reactive protein (hsCRP) is a marker for systemic inflammation and a risk marker for atherosclerotic cardiovascular disease (ACVD), and has also been associated with periodontitis. Inter-individual variation for hsCRP in periodontitis has been shown. ANRIL is the strongest genetic susceptibility locus for both periodontitis and ACVD, and it is speculated that genetic variation in ANRIL may modulate inflammatory processes. Therefore, we explored the possible association between hsCRP plasma levels and a leading ANRIL single nucleotide polymorphism (SNP) in periodontitis patients and controls. 171 healthy subjects with North European descent (115 periodontitis and 56 controls) were included in this case-control study. hsCRP levels were determined and subjects were genotyped for the leading ANRIL SNP rs1333048. In a multivariate analysis, periodontitis, female gender, increasing BMI and homozygosity for the major allele (AA-genotype) of rs1333048 were significantly associated with elevated hsCRP plasma levels (p = 0.012, p = 0.004, p = 0.007 and p = 0.003, respectively). Periodontitis patients with rs1333048 AA-genotype showed higher levels of hsCRP than those carrying the minor C allele (median: 4.5 mg/L vs. 1.6 mg/L, padjusted = 0.007). This study is the first to show that, in addition to gender and BMI, also a leading SNP in ANRIL is explanatory for inter-individual variation in hsCRP levels in periodontitis patients of North European descent.
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