ReviewBioMed research international2015
Motor Neuron Diseases in Sub-Saharan Africa: The Need for More Population-Based Studies.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub-Saharan Africa: A Narrative Review.Health science reports · 2026Article
- A rapid educational intervention to enhance brain MRI interpretation skills of radiology professionals for dementia diagnosis in Uganda: a pre- and post-intervention study.BMC medical education · 2026Article
- Promoting training for African medical students and residents in designing and conducting neurological oncogenetic research: A viewpoint.Surgical neurology international · 2026Article
- Analysis and comparison of the trends in the burden of motor neuron disease in China and worldwide from 1990 to 2021.PloS one · 2026Article
- ALS in Africa: current knowledge and exciting opportunities for future study - short communication.Annals of medicine and surgery (2012) · 2023Article
- Current status and future directions of amyotrophic lateral sclerosis research in Africa: a perspective.Annals of medicine and surgery (2012) · 2023Article
- In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2023Article
- Neuroscience education and research in Cameroon: Current status and future direction.IBRO neuroscience reports · 2021Article
- The Interplay Between Neuroinfections, the Immune System and Neurological Disorders: A Focus on Africa.Frontiers in immunology · 2021Review
- Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook.Malaria journal · 2019Article
- Can Proprioceptive Training Reduce Muscle Fatigue in Patients With Motor Neuron Diseases? A New Direction of Treatment.Frontiers in physiology · 2019Review
- Neuroscience in Nigeria: the past, the present and the future.Metabolic brain disease · 2018Review
- Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Genetic testing in ALS: A survey of current practices.Neurology · 2017Review
- Neuroscience-related research in Ghana: a systematic evaluation of direction and capacity.Metabolic brain disease · 2016Review
- Social Factors Influencing Child Health in Ghana.PloS one · 2016Review
- Developing expertise in bioinformatics for biomedical research in Africa.Applied & translational genomics · 2015Article
- Neurogenomics: An opportunity to integrate neuroscience, genomics and bioinformatics research in Africa.Applied & translational genomics · 2015Review
- Neurogenomics: Challenges and opportunities for Ghana.Applied & translational genomics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor neuron diseases (MNDs) are devastating neurological diseases that are characterised by gradual degeneration and death of motor neurons. Major types of MNDs include amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). These diseases are incurable, with limited disease-modifying treatment options. In order to improve MND-based biomedical research, drug development, and clinical care, population-based studies will be important. These studies, especially among less-studied populations, might identify novel factors controlling disease susceptibility and resistance. To evaluate progress in MND research in Africa, we examined the published literature on MNDs in Sub-Saharan Africa to identify disease prevalence, genetic factors, and other risk factors. Our findings indicate that the amount of research evidence on MNDs in Sub-Saharan Africa is scanty; molecular and genetics-based studies are particularly lacking. While only a few genetic studies were identified, these studies strongly suggest that there appear to be population-specific causes of MNDs among Africans. MND genetic underpinnings vary among different African populations and also between African and non-African populations. Further studies, especially molecular, genetic and genomic studies, will be required to advance our understanding of MND biology among African populations. Insights from these studies would help to improve the timeliness and accuracy of clinical diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.