Evidence map›Paper›PMID 26347875›Full record

Trial reportBioMed research international2015

Knee Flexion and Daily Activities in Patients following Total Knee Replacement: A Comparison with ISO Standard 14243.

Markus A Wimmer, William Nechtow, Thorsten Schwenke, Kirsten C Moisio

Abstract readClinical Trial
In one paragraph

Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Human-Interface Dynamics of Knee Exoskeletons with Lateral and Anteroposterior Attachment.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Varus or valgus positioning of the tibial component of a unicompartmental fixed-bearing knee arthroplasty does not increase wear.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Markus A WimmerDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
William NechtowDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Thorsten SchwenkeDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Kirsten C MoisioFeinberg School of Medicine, Northwestern University, Chicago, IL 60610, USA.

Funding

Wear Testing for Enhanced Prediction of TKR Clinical PerformanceR01AR059843 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI WIMMER, MARKUS ANTON · 2011 to 2014
$1.4M
Daily Activity of TKR Patients as Input for Wear TestingR03AR052039 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI WIMMER, MARKUS ANTON · 2006 to 2008
$216k
NIAMS NIH HHS R01 AR059843NIAMS NIH HHS R03 AR052039
6 · The paper itself

Abstract

Walking is only one of many daily activities performed by patients following total knee replacement (TKR). The purpose of this study was to examine the hypotheses (a) that subject activity characteristics are correlated with knee flexion range of motion (ROM) and (b) that there is a significant difference between the subject's flexion/extension excursion throughout the day and the ISO specified input for knee wear testing. In order to characterize activity, the number of walking and stair stepping cycles, the time spent with dynamic and stationary activities, the number of activity sequences, and the knee flexion/extension excursion of 32 TKR subjects were collected during daily activity. Flexion/extension profiles were compared with the ISO 14243 simulator input profile using a level crossing classification algorithm. Subjects took an average of 3102 (range: 343-5857) walking cycles including 65 (range: 0-319) stair stepping cycles. Active and passive ROMs were positively correlated with stair walking time, stair step counts, and stair walking sequences. Simulated knee motion according to ISO showed significantly fewer level crossings at the flexion angles 20-40° and beyond 50° than those measured with the monitor. This suggests that implant wear testing protocols should contain more cycles and a variety of activities requiring higher knee flexion angles with incorporated resting/transition periods to account for the many activity sequences.

Indexed as

Activities of Daily LivingArthroplasty, Replacement, KneeRange of Motion, ArticularWalkingAgedAged, 80 and overFemaleHumansMale

Identifiers

PMID26347875
PMCPMC4548073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.