ArticleFrontiers in cellular and infection microbiology2015
Targeted salivary biomarkers for discrimination of periodontal health and disease(s).
Article in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Assessment of salivary matrix metalloproteinase (MMP8) and activated salivary matrix metalloproteinase (aMMP8) in periodontitis patients: a systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Is there any association between the presence of biomarkers and apical periodontitis? A systematic review.Frontiers in immunology · 2024Pooled it
- Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.Scientific reports · 2021Trial
- Differential profiles of soluble and cellular toll like receptor (TLR)-2 and 4 in chronic periodontitis.PloS one · 2018Trial
- Essential Oil-Containing Mouthrinses for Plaque and Gingivitis Control: Formulation Chemistry, Human Salivary Biomarkers, Mechanistic Evidence, and Research Priorities.Molecules (Basel, Switzerland) · 2026Review
- Salivary antibody responses toJournal of advanced periodontology & implant dentistry · 2026Article
- Extraoral Detection of Biomarkers and Pathogens in Saliva: Comprehensive, Panoramic Review.Biosensors · 2026Review
- Diagnostic Potential of aMMP-8 PoCT in Oral Fluids: Insights from Periodontitis and Metabolic Syndrome Interplay.European journal of dentistry · 2026Article
- TAM pathway proteins as novel salivary biomarkers for periodontitis.Journal of periodontology · 2026Observational
- Electrochemical and optical biosensors for periodontitis detection.Biochemistry and biophysics reports · 2026Review
- Potential biomarkers for early periodontal inflammation: investigating CD5Scientific reports · 2026Article
- Innovative Biomarkers for Oral Immunity: Advancements and Clinical Applications.Advances in experimental medicine and biology · 2026Review
- Fibrinogen was associated with subgingival microbiome in periodontal diseases: a pilot study.Journal of oral microbiology · 2026Article
- Establishing cut-off values for salivary MMP-8 and IL-1β in the diagnosis of active periodontal disease: a preliminary cohort study toward the development of a diagnostic kit.Journal of periodontal & implant science · 2025Article
- Salivary Biomarkers in Periodontal Disease: Revolutionizing Early Detection and Precision Dentistry.Molecular diagnosis & therapy · 2025Review
- Gingivo-Periodontal Alterations in Pediatric Leukemia: A Comparative Analysis of IL-1β, IL-6, IL-17α and TGF-β1 Levels in Gingival Crevicular Fluid and Plasma.Dentistry journal · 2025Article
- Article
- Correlation between concentrations of salivary and gingival crevicular fluid inflammatory cytokines in patients with gingivitis and periodontitis and healthy individuals.Journal of advanced periodontology & implant dentistry · 2025Article
- Meteorin-like levels of oral fluids in periodontal health and diseases: a comparative cross-sectional study.Clinical oral investigations · 2025Article
- Salivary features of periodontitis and gingivitis in type 2 diabetes mellitus.Scientific reports · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledGenerally, clinical parameters are used in dental practice for periodontal disease, yet several drawbacks exist with the clinical standards for addressing the needs of the public at large in determining the current status/progression of the disease, and requiring a significant amount of damage before these parameters can document disease. Therefore, a quick, easy and reliable method of assessing and monitoring periodontal disease should provide important diagnostic information that improves and speeds treatment decisions and moves the field closer to individualized point-of-care diagnostics.
objectiveThis report provides results for a saliva-based diagnostic approach for periodontal health and disease based upon the abundance of salivary analytes coincident with disease, and the significant progress already made in the identification of discriminatory salivary biomarkers of periodontitis.
methodsWe evaluated biomarkers representing various phases of periodontitis initiation and progression (IL-1ß, IL-6, MMP-8, MIP-1α) in whole saliva from 209 subjects categorized with periodontal health, gingivitis, and periodontitis.
resultsEvaluation of the salivary analytes demonstrated utility for individual biomarkers to differentiate periodontitis from health. Inclusion of gingivitis patients into the analyses provided a more robust basis to estimate the value of each of these analytes. Various clinical and statistical approaches showed that pairs or panels of the analytes were able to increase the sensitivity and specificity for the identification of disease.
conclusionsSalivary concentrations of IL-1ß, IL-6, MMP-8, MIP-1α alone and in combination are able to distinguish health from gingivitis and periodontitis. The data clearly demonstrated a heterogeneity in response profiles of these analytes that supports the need for refinement of the standard clinical classifications if we are to move toward precision/personalized dentistry for the twenty-first century.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.