ArticleProstate cancer2015
Analysis of Prostate Cancer Susceptibility Variants in South African Men: Replicating Associations on Chromosomes 8q24 and 10q11.
Article in Prostate cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.Genome biology · 2022Article
- Review of prostate cancer genomic studies in Africa.Frontiers in genetics · 2022Review
- The Cancer Prevention Project of Philadelphia: preliminary findings examining diversity among the African diaspora.Ethnicity & health · 2021Article
- The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision Medicine.Genes · 2020Review
- A Custom Genotyping Array Reveals Population-Level Heterogeneity for the Genetic Risks of Prostate Cancer and Other Cancers in Africa.Cancer research · 2020Article
- Review
- Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.The Prostate · 2017Article
- Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population.Oncotarget · 2017Article
- Racial disparities in prostate cancer: a molecular perspective.Frontiers in bioscience (Landmark edition) · 2017Review
- Prostate Cancer Genomics Research Disparities in Africa: Advancing Knowledge in Resource Constrained Settings.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies (GWAS) have implicated single nucleotide polymorphisms (SNPs) on chromosomes 2p15, 6q25, 7p15.2, 7q21, 8q24, 10q11, 10q26, 11q13, 17q12, 17q24, 19q13, and Xp11, with prostate cancer (PCa) susceptibility and/or tumour aggressiveness, in populations of African, European, and Asian ancestry. The objective of this study was to confirm these associations in South African Mixed Ancestry and White men. We evaluated 17 prioritised GWAS SNPs in South African cases (331 Mixed Ancestry and 155 White) and controls (178 Mixed Ancestry and 145 White). The replicated SNP associations for the different South African ethnic groups were rs7008482 (8q24) (p = 2.45 × 10(-5)), rs6983267 (8q24) (p = 4.48 × 10(-7)), and rs10993994 (10q11) (p = 1.40 × 10(-3)) in Mixed Ancestry men and rs10993994 (p = 1.56 × 10(-9)) in White men. No significant associations were observed for the analyses stratified by disease aggressiveness in the individual and the combined population group analysis. The present study demonstrates that a number of known PCa susceptibility variants may contribute to disease susceptibility in South African men. Larger genetic investigations extended to other South African population groups are warranted to confirm the role of these and other SNPs in disease susceptibility.
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Registered trials
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