ArticleISBT science series2015
Red blood cell transfusion-induced inflammation: myth or reality.
Article in ISBT science series, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- IgG2b enhances alloantibodies to stored red blood cells.Transfusion · 2025Article
- New frontiers in neonatal red blood cell transfusion research.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Modifiable Risk Factors and Preventative Strategies for Severe Retinopathy of Prematurity.Life (Basel, Switzerland) · 2023Review
- Article
- Prevalence and risk factor of post-operative lower extremities deep vein thrombosis in patients undergoing gynecologic surgery: a single-institute cross-sectional study.Thrombosis journal · 2022Article
- Blood transfusions increase the risk for venous thromboembolism events following total joint arthroplasty.Scientific reports · 2021Article
- Incidence of venous thromboembolism after standard treatment in patients with epithelial ovarian cancer in Korea.Cancer medicine · 2021Article
- Review
- Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry.JAMA surgery · 2018Article
- Two-way Interaction Effects of Perioperative Complications on 30-Day Mortality in General Surgery.World journal of surgery · 2018Article
- Duration of red blood cell storage and inflammatory marker generation.Blood transfusion = Trasfusione del sangue · 2017Review
- Red blood cell antigen alloimmunization: Mysteries still unsolved.EBioMedicine · 2016Article
- Addition of Sodium Pyruvate to Stored Red Blood Cells Attenuates Liver Injury in a Murine Transfusion Model.Mediators of inflammation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Red blood cells (RBCs) destined for transfusion can be refrigerator stored for up to 42 days prior to transfusion. Our studies in mice and dogs suggest that transfusion of older, stored RBCs, but not fresh RBCs, produce acute elevations in circulating pro-inflammatory cytokine levels. Although our study in healthy adult human volunteers failed to demonstrate a pro-inflammatory cytokine response following transfusion of RBCs stored for 40-42 days, a recent study in preterm infants suggests that RBC transfusions are associated with a pro-inflammatory response. Thus, whether RBC transfusions, particularly of older, stored RBCs, result in a pro-inflammatory cytokine response, is still an unresolved issue. Animal studies suggest this to be true, yet human studies have yet to demonstrate definitively that such an inflammatory response occurs. Potential explanations for this include differences between human and animal biology, the dose of RBCs transfused, and baseline differences in levels of inflammation. This review will summarize the currently available evidence and approaches to resolving whether transfusions of older, stored RBCs are associated with inflammation in recipients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.