Evidence map›Paper›PMID 26347778›Full record

ArticleInternational journal of dentistry2015

In Vitro Effect of Zingiber officinale Extract on Growth of Streptococcus mutans and Streptococcus sanguinis.

Arash Azizi, Shabnam Aghayan, Saeed Zaker, Mahdieh Shakeri, Navid Entezari, Shirin Lawaf

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03061916 (Antimicrobial Effects of Aqueous Extracts of Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03061916 phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Antimicrobial Effects of Aqueous Extracts of Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans

TypeinterventionalSponsorCairo UniversityRan2017 to 2017Enrolled21ConditionsDental CariesArmsCinnamon, Ginger, Chlorhexidine Gluconate
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Novel Amides Derivative with Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2021
    Article
  8. Review
  9. Influence of Medicinal Plant Extracts on the Growth of Oral PathogensOpen access Macedonian journal of medical sciences · 2019
    Article
  10. Article
  11. Journal of advanced research · 2016
    Article
  12. Antimicrobial activity of Curcuma amada extract on Streptococcus mutans-AnJournal of oral and maxillofacial pathology : JOMFP
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arash AziziOral Medicine Department, Islamic Azad University Dental Branch, Tehran, Iran.
Shabnam AghayanPeriodontics Department, Islamic Azad University Dental Branch, Tehran, Iran.
Saeed ZakerMicrobiology Department, Islamic Azad University, Parand Branch, Tehran, Iran.
Mahdieh ShakeriIslamic Azad University Dental Branch, Tehran, Iran.
Navid EntezariIslamic Azad University Dental Branch, Tehran, Iran.
Shirin LawafProsthodontics Department, Islamic Azad University Dental Branch, Tehran, Iran.
Islamic Azad University Dental Branch of Tehran · IRIslamic Azad University of Parand · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives. Tooth decay is an infectious disease of microbial origin. Considering the increasing prevalence of antibiotic resistance due to their overuse and also their side effects, medicinal plants are now considered for use against bacterial infections. This study aimed to assess the effects of different concentrations of Zingiber officinale extract on proliferation of Streptococcus mutans and Streptococcus sanguinis in vitro. Materials and Methods. In this experimental study, serial dilutions of the extract were prepared in two sets of 10 test tubes for each bacterium (total of 20). Standard amounts of bacterial suspension were added; 100ƛ of each tube was cultured on prepared solid agar plates and incubated at 37°C for 24 hours. Serial dilutions of the extract were prepared in another 20 tubes and 100ƛ of each tube was added to blood agar culture medium while being prepared. The mixture was transferred to the plates. The bacteria were inoculated on plates and incubated as described. Results. The minimum inhibitory concentration (MIC) was 0.02 mg/mL for S. mutans and 0.3 mg/mL for S. sanguinis. The minimum bactericidal concentration (MBC) was 0.04 mg for S. mutans and 0.6 mg for S. sanguinis. Conclusion. Zingiber officinale extract has significant antibacterial activity against S. mutans and S. sanguinis cariogenic microorganisms.

Identifiers

PMID26347778
PMCPMC4549545
OpenAlexW2155019393

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.