ArticleFrontiers in plant science2015
The protein disulfide isomerase 1 of Phytophthora parasitica (PpPDI1) is associated with the haustoria-like structures and contributes to plant infection.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein RACK1.Molecular plant pathology · 2026Article
- The Phytophthora infestans effector Pi05910 suppresses and destabilizes host glycolate oxidase StGOX4 to promote plant susceptibility.Molecular plant pathology · 2024Article
- Protein Disulfide Isomerase FgEps1 Is a Secreted Virulence Factor inJournal of fungi (Basel, Switzerland) · 2023Article
- Differential Protein Expression ofPathogens (Basel, Switzerland) · 2023Article
- ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions.Experimental & molecular medicine · 2023Article
- A conserved protein disulfide isomerase enhances plant resistance against herbivores.Plant physiology · 2023Article
- Mutations in PpAGO3 Lead to Enhanced Virulence ofFrontiers in microbiology · 2022Article
- The thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses.BMC plant biology · 2021Article
- Haustorium formation and a distinct biotrophic transcriptome characterize infection of Nicotiana benthamiana by the tree pathogen Phytophthora kernoviae.Molecular plant pathology · 2021Article
- An Improved Transformation System forFrontiers in microbiology · 2021Article
- Nitrogen Supply and Host-Plant Genotype Modulate the Transcriptomic Profile ofFrontiers in microbiology · 2021Article
- Identification and Characterization of a Novel Protein Disulfide Isomerase Gene (International journal of molecular sciences · 2020Article
- Devastating intimacy: the cell biology of plant-Phytophthora interactions.The New phytologist · 2020Review
- A novel plant protein-disulfide isomerase participates in resistance response against the TYLCV in tomato.Planta · 2020Article
- Planthopper-Secreted Salivary Disulfide Isomerase Activates Immune Responses in Plants.Frontiers in plant science · 2020Article
- Meloidogyne graminicola protein disulfide isomerase may be a nematode effector and is involved in protection against oxidative damage.Scientific reports · 2019Article
- An RXLR effector secreted by Phytophthora parasitica is a virulence factor and triggers cell death in various plants.Molecular plant pathology · 2019Article
- Article
- Quantitative Proteomics of Potato Leaves Infected withInternational journal of molecular sciences · 2019Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein disulfide isomerase (PDI) is a ubiquitous and multifunction enzyme belonging to the thioredoxin (TRX) superfamily, which can reduce, oxidize, and catalyze dithiol-disulfide exchange reactions. Other than performing housekeeping functions in helping to maintain proteins in a more stable conformation, there is some evidence to indicate that PDI is involved in pathogen infection processes. In a high-throughput screening for necrosis-inducing factors by Agrobacterium tumefaciens-mediated transient expression assay, a typical PDI gene from Phytophthora parasitica (PpPDI1) was identified and confirmed to induce strong cell death in Nicotiana benthamiana leaves. PpPDI1 is conserved in eukaryotes but predicted to be a secreted protein. Deletion mutant analyses showed that the first CGHC motif in the active domain of PpPDI1 is essential for inducing cell death. Using P. parasitica transformation method, the silencing efficiency was found to be very low, suggesting that PpPDI1 is essential for the pathogen. Translational fusion to the enhanced green fluorescent protein (EGFP) in stable P. parasitica transformants showed that PpPDI1 is associated with haustoria-like structures during pathogen infection. Furthermore, the PpPDI1-EGFP-expressing transformants increase the number of haustoria-like structures and exhibit enhanced virulence to N. benthamiana. These results indicate that PpPDI1 might be a virulence factor of P. parasitica and contributes to plant infection.
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