ReviewFrontiers in microbiology2015
The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Interaction of the SXT/R391 element ICEMicrobiology spectrum · 2025Article
- Genomic characterization ofFrontiers in microbiology · 2025Article
- Surface exclusion of IncC conjugative plasmids and their relatives.PLoS genetics · 2024Article
- A comprehensive list of genes required for the efficient conjugation of plasmid Rts1 was determined by systematic deletion analysis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Identification of IncA Plasmid, HarboringAntibiotics (Basel, Switzerland) · 2023Article
- An Integrative and Conjugative Element (ICE) Found in Shewanella halifaxensis Isolated from Marine Fish Intestine May Connect Genetic Materials between Human and Marine Environments.Microbes and environments · 2022Article
- Comparative genomics reveals new insights into the evolution of the IncA and IncC family of plasmids.Frontiers in microbiology · 2022Article
- Life Within a Contaminated Niche: Comparative Genomic Analyses of an Integrative Conjugative Element ICEFrontiers in microbiology · 2022Article
- Crucial role of Salmonella genomic island 1 master activator in the parasitism of IncC plasmids.Nucleic acids research · 2021Article
- Geographical distribution and antibiotics susceptibility patterns of toxigenic Vibrio cholerae isolates from Kisumu County, Kenya.African journal of primary health care & family medicine · 2020Article
- Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss.PLoS genetics · 2020Article
- Article
- Identification and Characterization ofFrontiers in microbiology · 2019Article
- Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Characterization of a Novel SXT/R391 Integrative and Conjugative Element CarryingAntimicrobial agents and chemotherapy · 2018Article
- Draft Genome Sequence of a Shewanella halifaxensis Strain Isolated from the Intestine of Marine Red Seabream (Pagrus major), Which Includes an Integrative Conjugative Element with Macrolide Resistance Genes.Genome announcements · 2018Article
- Comparative Genomic Analysis of a Clinical Isolate ofFrontiers in microbiology · 2018Article
- The hidden life of integrative and conjugative elements.FEMS microbiology reviews · 2017Review
- Salmonella genomic island 1 (SGI1) reshapes the mating apparatus of IncC conjugative plasmids to promote self-propagation.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, healthcare systems are challenged by a major worldwide drug resistance crisis caused by the massive and rapid dissemination of antibiotic resistance genes and associated emergence of multidrug resistant pathogenic bacteria, in both clinical and environmental settings. Conjugation is the main driving force of gene transfer among microorganisms. This mechanism of horizontal gene transfer mediates the translocation of large DNA fragments between two bacterial cells in direct contact. Integrative and conjugative elements (ICEs) of the SXT/R391 family (SRIs) and IncA/C conjugative plasmids (ACPs) are responsible for the dissemination of a broad spectrum of antibiotic resistance genes among diverse species of Enterobacteriaceae and Vibrionaceae. The biology, diversity, prevalence and distribution of these two families of conjugative elements have been the subject of extensive studies for the past 15 years. Recently, the transcriptional regulators that govern their dissemination through the expression of ICE- or plasmid-encoded transfer genes have been described. Unrelated repressors control the activation of conjugation by preventing the expression of two related master activator complexes in both types of elements, i.e., SetCD in SXT/R391 ICEs and AcaCD in IncA/C plasmids. Finally, in addition to activating ICE- or plasmid-borne genes, these master activators have been shown to specifically activate phylogenetically unrelated mobilizable genomic islands (MGIs) that also disseminate antibiotic resistance genes and other adaptive traits among a plethora of pathogens such as Vibrio cholerae and Salmonella enterica.
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