ArticleFrontiers in microbiology2015
The use of phage FCL-2 as an alternative to chemotherapy against columnaris disease in aquaculture.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 81 citations in OpenAlex.
- Examining the Effects: Lack of Impact by Endolysin and Phage Treatment on Rotifer and Larvae Microbiota.Antibiotics (Basel, Switzerland) · 2026Article
- Bacteriophage Therapy in Freshwater and Saltwater Aquaculture Species.Microorganisms · 2025Review
- Tunturi virus isolates and metagenome-assembled viral genomes provide insights into the virome of Acidobacteriota in Arctic tundra soils.Microbiome · 2025Article
- Bacterial diseases in Siniperca chuatsi: status and therapeutic strategies.Veterinary research communications · 2024Review
- A Concise Overview of Studies on Successful Real-World Applications of Bacteriophages in Aquaculture.Viruses · 2024Review
- Gliding motility proteins GldJ and SprB contribute toJournal of bacteriology · 2024Article
- Phage therapy minimally affects the water microbiota in an Atlantic salmon (Salmo salar) rearing system while still preventing infection.Scientific reports · 2023Article
- Bacterial diseases in marine fish species: current trends and future prospects in disease management.World journal of microbiology & biotechnology · 2023Review
- Catfishes: A global review of the literature.Heliyon · 2023Review
- Reversible mutations in gliding motility and virulence genes: A flexible and efficient phage defence mechanism in Flavobacterium psychrophilum.Environmental microbiology · 2022Article
- Bacteriophage therapy in aquaculture: current status and future challenges.Folia microbiologica · 2022Review
- Conserved QTL and chromosomal inversion affect resistance to columnaris disease in 2 rainbow trout (Oncorhyncus mykiss) populations.G3 (Bethesda, Md.) · 2022Article
- In Vivo Bacteriophages' Application for the Prevention and Therapy of Aquaculture Animals-Chosen Aspects.Animals : an open access journal from MDPI · 2022Review
- Prevalence of genetically similar Flavobacterium columnare phages across aquaculture environments reveals a strong potential for pathogen control.Environmental microbiology · 2022Article
- Phenotypic and Genetic Characterization ofViruses · 2022Article
- Bacteriophages in the Control ofAntibiotics (Basel, Switzerland) · 2022Review
- Phage Therapy as a Focused Management Strategy in Aquaculture.International journal of molecular sciences · 2021Review
- Comparison of Delivery Methods in Phage Therapy againstAntibiotics (Basel, Switzerland) · 2021Article
- Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System.Applied and environmental microbiology · 2021Article
- Interactions between Rainbow Trout Eyed Eggs andMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavobacterium columnare, the causative agent of columnaris disease in fish, causes millions of dollars of losses in the US channel catfish industry alone, not to mention aquaculture industry worldwide. Novel methods are needed for the control and treatment of bacterial diseases in aquaculture to replace traditionally used chemotherapies. A potential solution could be the use of phages, i.e., bacterial viruses, host-specific and self-enriching particles that can be can easily distributed via water flow. We examined the efficacy of phages to combat columnaris disease. A previously isolated phage, FCL-2, infecting F. columnare, was characterized by sequencing. The 47 142 bp genome of the phage had G + C content of 30.2%, and the closest similarities regarding the structural proteins were found in Cellulophaga phage phiSM. Under controlled experimental conditions, two host fish species, rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio), were used to study the success of phage therapy to prevent F. columnare infections. The survival of both fish species was significantly higher in the presence of the phage. Hundred percent of the zebrafish and 50% of the rainbow trout survived in the phage treatment (survival without phage 0 and 8.3%, respectively). Most importantly, the rainbow trout population was rescued from infection by a single addition of the phage into the water in a flow-through fish tank system. Thus, F. columnare could be used as a model system to test the benefits and risks of phage therapy on a larger scale.
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