ReviewFrontiers in behavioral neuroscience2015
At the frontier of epigenetics of brain sex differences.
Review in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Sex-specific DNA methylation differences in Alzheimer's disease pathology.Acta neuropathologica communications · 2021Pooled it
- The Effects of Hormonal Contraceptives on the Brain: A Systematic Review of Neuroimaging Studies.Frontiers in psychology · 2020Pooled it
- Article
- Seasonal timing in a changing world: the epigenetic link between environment and reproduction across taxa.Environmental epigenetics · 2026Article
- Microglial interferon signaling and Aβ plaque pathology are enhanced in female 5xFAD Alzheimer's disease mice, independent of estrous cycle stage.Journal of neuroinflammation · 2025Article
- Early-Life Adversity and Epigenetic Aging: Findings from a 17-Year Longitudinal Study.Biomolecules · 2025Article
- Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.Environmental health perspectives · 2024Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies.Genes · 2024Review
- Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology.Hormones and behavior · 2024Article
- Minding the Gap: Exploring Neuroinflammatory and Microglial Sex Differences in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.Scientific reports · 2023Article
- Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines.Metabolites · 2023Article
- The sex-dependent response to psychosocial stress and ischaemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Sex-specific DNA methylation: impact on human health and development.Molecular genetics and genomics : MGG · 2022Review
- Epigenetic Mechanisms of Brain Sexual Differentiation.Cold Spring Harbor perspectives in biology · 2022Review
- Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring.Epigenetics & chromatin · 2022Article
- Resilience to Stress: Lessons from Rodents about Nature versus Nurture.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Review
- Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC).The European journal of neuroscience · 2022Review
- The Role of Transposable Elements in Sexual Development.Frontiers in behavioral neuroscience · 2022Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The notion that epigenetics may play an important role in the establishment and maintenance of sex differences in the brain has garnered great enthusiasm but the reality in terms of actual advances has been slow. Two general approaches include the comparison of a particular epigenetic mark in males vs. females and the inhibition of key epigenetic enzymes or co-factors to determine if this eliminates a particular sex difference in brain or behavior. The majority of emphasis has been on candidate genes such as steroid receptors. Only recently have more generalized survey type approaches been achieved and these promise to open new vistas and accelerate discovery of important roles for DNA methylation, histone modification, genomic imprinting and microRNAs (miRs). Technical challenges abound and, while not unique to this field, will require novel thinking and new approaches by behavioral neuroendocrinologists.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.