ArticleFrontiers in systems neuroscience2015
Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding.
Article in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.The international journal of neuropsychopharmacology · 2025Article
- Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility.Science advances · 2024Article
- Sharpening the blades of the dentate gyrus: how adult-born neurons differentially modulate diverse aspects of hippocampal learning and memory.The EMBO journal · 2023Review
- Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: A potential role of adult hippocampal neurogenesis in "curiosity".The Journal of comparative neurology · 2023Article
- Dysregulation ofLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience?International journal of molecular sciences · 2021Review
- Effects of classical PKC activation on hippocampal neurogenesis and cognitive performance: mechanism of action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Morris Water Maze and Contextual Fear Conditioning Tasks to Evaluate Cognitive Functions Associated With Adult Hippocampal Neurogenesis.Frontiers in neuroscience · 2021Review
- Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.Nature communications · 2020Article
- Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons.Cell reports · 2020Article
- Forgetting at biologically realistic levels of neurogenesis in a large-scale hippocampal model.Behavioural brain research · 2019Article
- Functions of adult-born neurons in hippocampal memory interference and indexing.Nature neuroscience · 2019Review
- Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.Hippocampus · 2019Article
- Associations between atherosclerosis and neurological diseases, beyond ischemia-induced cerebral damage.Reviews in endocrine & metabolic disorders · 2019Review
- Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia.Frontiers in cell and developmental biology · 2019Review
- Sex specific effects of pre-pubertal stress on hippocampal neurogenesis and behaviour.Translational psychiatry · 2018Article
- Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates.Frontiers in neuroanatomy · 2018Review
- Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The dentate gyrus (DG) of mammals harbors neural stem cells that generate new dentate granule cells (DGCs) throughout life. Behavioral studies using the contextual fear discrimination paradigm have found that selectively augmenting or blocking adult hippocampal neurogenesis enhances or impairs discrimination under conditions of high, but not low, interference suggestive of a role in pattern separation. Although contextual discrimination engages population-based coding mechanisms underlying pattern separation such as global remapping in the DG and CA3, how adult hippocampal neurogenesis modulates pattern separation in the DG is poorly understood. Here, we propose a role for adult-born DGCs in re-activation coupled modulation of sparseness through feed-back inhibition to govern global remapping in the DG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.