ArticleFrontiers in neuroanatomy2015
The anatomical problem posed by brain complexity and size: a potential solution.
Article in Frontiers in neuroanatomy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Layer-specific cellular composition of mouse primary somatosensory and human temporal cortex: a direct 3D confocal counting approach.Frontiers in neuroanatomy · 2026Article
- Generating brain-wide connectome using synthetic axonal morphologies.Nature communications · 2025Article
- Volume electron microscopy reveals unique laminar synaptic characteristics in the human entorhinal cortex.eLife · 2025Article
- Laminar pattern of sensory-evoked dynamic high-frequency oscillatory activity in the macaque auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Volume electron microscopy analysis of synapses in primary regions of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Key morphological features of human pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Extended reality in cranial and spinal neurosurgery - a bibliometric analysis.Acta neurochirurgica · 2024Review
- Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024Review
- A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites.PLoS computational biology · 2024Article
- 3D synaptic organization of layer III of the human anterior cingulate and temporopolar cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe.eLife · 2023Article
- Mapping the primate thalamus: systematic approach to analyze the distribution of subcortical neuromodulatory afferents.Brain structure & function · 2023Article
- Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew.The Journal of comparative neurology · 2023Article
- Smart imaging to empower brain-wide neuroscience at single-cell levels.Brain informatics · 2022Review
- Three-Dimensional Synaptic Organization of Layer III of the Human Temporal Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- 3D Ultrastructural Study of Synapses in the Human Entorhinal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Recent progress in translational engineered in vitro models of the central nervous system.Brain : a journal of neurology · 2020Review
- Multi-aspect testing and ranking inference to quantify dimorphism in the cytoarchitecture of cerebellum of male, female and intersex individuals: a model applied to bovine brains.Brain structure & function · 2020Article
- Anatomy and Physiology of Macaque Visual Cortical Areas V1, V2, and V5/MT: Bases for Biologically Realistic Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Review
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Abstract
Over the years the field of neuroanatomy has evolved considerably but unraveling the extraordinary structural and functional complexity of the brain seems to be an unattainable goal, partly due to the fact that it is only possible to obtain an imprecise connection matrix of the brain. The reasons why reaching such a goal appears almost impossible to date is discussed here, together with suggestions of how we could overcome this anatomical problem by establishing new methodologies to study the brain and by promoting interdisciplinary collaboration. Generating a realistic computational model seems to be the solution rather than attempting to fully reconstruct the whole brain or a particular brain region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.