Evidence map›Paper›PMID 26347604›Full record

ReviewFrontiers in neuroscience2015

Disease-modifying therapeutic directions for Lewy-Body dementias.

Qiang Zhang, Young-Cho Kim, Nandakumar S Narayanan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Approach to Cognitive Impairment in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qiang ZhangDepartment of Neurology, University of Iowa Iowa City, IA, USA ; Physician Scientist Training Program, University of Iowa Iowa City, IA, USA.
Young-Cho KimDepartment of Neurology, University of Iowa Iowa City, IA, USA.
Nandakumar S NarayananDepartment of Neurology, University of Iowa Iowa City, IA, USA ; Aging Mind and Brain Initiative, Carver College of Medicine, University of Iowa Iowa City, IA, USA.
University of Iowa · US

Funding

Prefrontal D1 signaling and cognitive symptoms of Parkinson's diseaseR01NS089470 · NINDS · UNIVERSITY OF IOWA · PI NARAYANAN, NANDAKUMAR · 2014 to 2018
$1.6M
Prefrontal dopamine and cognitive symptoms of Parkinsons diseaseK08NS078100 · NINDS · YALE UNIVERSITY · PI NARAYANAN, NANDAKUMAR · 2012 to 2016
$908k
NINDS NIH HHS K08 NS078100NINDS NIH HHS R01 NS089470
6 · The paper itself

Abstract

Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB.

Indexed as

Alzheimer's diseaseDeep Brain StimulationDementia with Lewy Bodiesdisease-modifying therapyParkinson's disease

Identifiers

PMID26347604
PMCPMC4542461
OpenAlexW1732593065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.