ArticleThe Journal of infectious diseases2016
Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Development andMicrobiology spectrum · 2026Article
- Prevalence, Virulence, and Pathogenic Mechanisms of Mastitis-AssociatedVeterinary sciences · 2026Review
- A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- A combined genetic and phenotypic marker approach enables precise detection of hypervirulentMicrobiology spectrum · 2026Article
- Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium.npj antimicrobials and resistance · 2026Article
- Bacterial adhesion strategies and countermeasures in urinary tract infection.Nature microbiology · 2025Review
- Virulence of Bacteria Causing Mastitis in Dairy Cows: A Literature Review.Microorganisms · 2025Review
- Virulence factors of bovine mastitis pathogens: distribution, pathogenesis, and emerging vaccines targeting virulence factors: a literature review.Frontiers in veterinary science · 2025Review
- Genomic analysis of the first multidrug-resistant ESBL-producing high-risk clonal lineage Klebsiella pneumoniae ST147 isolated from a cat with urinary tract infection.Veterinary research communications · 2024Article
- Article
- Photodynamic Therapy of LD4-Photosensitizer Attenuates the Acute Pneumonia Induced byACS pharmacology & translational science · 2024Article
- Interactions and Implications ofInfection and drug resistance · 2024Review
- RfaH contributes to maximal colonization and full virulence of hypervirulentFrontiers in cellular and infection microbiology · 2024Article
- Animal models ofFrontiers in microbiology · 2024Review
- Characterization of novel bacteriophage PSKP16 and its therapeutic potential against β-lactamase and biofilm producer strain of K2-Hypervirulent Klebsiella pneumoniae pneumonia infection in mice model.BMC microbiology · 2023Article
- Novel Virulence Factors DecipheringInternational journal of molecular sciences · 2022Article
- A review: Virulence factors ofVeterinary world · 2022Review
- Murine Respiratory Tract Infection with Classical Klebsiella pneumoniae Induces Bronchus-Associated Lymphoid Tissue.Infection and immunity · 2022Article
- Classical and γδ T cells are each independently sufficient to establish protection against a classical strain ofFrontiers in cellular and infection microbiology · 2022Article
- Metagenome Analysis of the Bacterial Characteristics in InvasiveFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Klebsiella pneumoniae, a chief cause of nosocomial pneumonia, is a versatile and commonly multidrug-resistant human pathogen for which further insight into pathogenesis is needed. We show that the pilus regulatory gene fimK promotes the virulence of K. pneumoniae strain TOP52 in murine pneumonia. This contrasts with the attenuating effect of fimK on urinary tract virulence, illustrating that a single factor may exert opposing effects on pathogenesis in distinct host niches. Loss of fimK in TOP52 pneumonia was associated with diminished lung bacterial burden, limited innate responses within the lung, and improved host survival. FimK expression was shown to promote serum resistance, capsule production, and protection from phagocytosis by host immune cells. Finally, while the widely used K. pneumoniae model strain 43816 produces rapid dissemination and death in mice, TOP52 caused largely localized pneumonia with limited lethality, thereby providing an alternative tool for studying K. pneumoniae pathogenesis and control within the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.