Evidence map›Paper›PMID 26347531›Full record

ArticleGut2016

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

Eva M Serrao, Mikko I Kettunen, Tiago B Rodrigues, Piotr Dzien, Alan J Wright, Aarthi Gopinathan, Ferdia A Gallagher, David Y Lewis, Kristopher K Frese, Jaime Almeida and 3 more

Open access · hybridAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Molecular Imaging: Unveiling Metabolic Abnormalities in Pancreatic Cancer.International journal of molecular sciences · 2025
    Review
  6. Review
  7. The regulatory roles and clinical significance of glycolysis in tumor.Cancer communications (London, England) · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. A Simulation of the Effects of Diffusion on Hyperpolarized [1-IEEE transactions on bio-medical engineering · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Multinuclear MRI in Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Review
  17. Review
  18. Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Eva M SerraoCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Mikko I KettunenCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Tiago B RodriguesCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Piotr DzienCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Alan J WrightCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Aarthi GopinathanCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ferdia A GallagherCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Radiology, University of Cambridge, Cambridge, UK.
David Y LewisCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Kristopher K FresePrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Jaime AlmeidaCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
William J HowatCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
David A TuvesonCold Spring Harbor Laboratory, New York, New York, USA.
Kevin M BrindleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK.
Cancer Research UK · GBUniversity of Cambridge · GBCold Spring Harbor Laboratory · USPrincess Margaret Cancer Centre · CA

Funding

Cancer Research UK 15678Cancer Research UK 16465Cancer Research UK 16628Cancer Research UK 17242
6 · The paper itself

Abstract

objectivesPancreatic cancer (PCa) is treatable by surgery when detected at an early stage. Non-invasive imaging methods able to detect both established tumours and their precursor lesions are needed to select patients for surgery. We investigated here whether pancreatic preneoplasia could be detected prior to the development of invasive cancers in genetically engineered mouse models of PCa using metabolic imaging.

designThe concentrations of alanine and lactate and the activities of lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) were measured in extracts prepared from the pancreas of animals at different stages of disease progression; from pancreatitis, through tissue with predominantly low-grade and then high-grade pancreatic intraepithelial neoplasia and then tumour. (13)C magnetic resonance spectroscopic imaging ((13)C-MRSI) was used to measure non-invasively changes in (13)C labelling of alanine and lactate with disease progression, following injection of hyperpolarised [1-(13)C]pyruvate.

resultsProgressive decreases in the alanine/lactate concentration ratio and ALT/LDH activity ratio with disease progression were accompanied by a corresponding decrease in the [1-(13)C]alanine/[1-(13)C]lactate signal ratio observed in (13)C-MRSI images of the pancreas.

conclusionsMetabolic imaging with hyperpolarised [1-(13)C]pyruvate enables detection and monitoring of the progression of PCa precursor lesions. Translation of this MRI technique to the clinic has the potential to improve the management of patients at high risk of developing PCa.

Indexed as

AnimalsBiomarkersCarbon-13 Magnetic Resonance SpectroscopyCarcinoma, Pancreatic DuctalDisease ProgressionMiceMice, TransgenicPancreasPancreatic NeoplasmsPancreatitisPrecancerous ConditionsPyruvic AcidBiomarkersPyruvic AcidCANCERMAGNETIC RESONANCE IMAGINGPANCREAS

Identifiers

PMID26347531
PMCPMC4789827
OpenAlexW2182190458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.