Evidence map›Paper›PMID 26347228›Full record

ArticleDevelopmental cognitive neuroscience2016

Toward an integrative science of the developing human mind and brain: Focus on the developing cortex.

Terry L Jernigan, Timothy T Brown, Hauke Bartsch, Anders M Dale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Prenatal tobacco exposure associations with physical health and neurodevelopment in the ABCD cohort.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023
    Article
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  11. Flux of life.Developmental cognitive neuroscience · 2019
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Mechanisms of Hierarchical Cortical Maturation.Frontiers in cellular neuroscience · 2017
    Review
  20. Individual differences in human brain development.Wiley interdisciplinary reviews. Cognitive science · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Terry L JerniganCenter for Human Development, University of California, San Diego, La Jolla, CA, United States; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, United States; Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States; Department of Radiology, University of California, San Diego, La Jolla, CA, United States. Electronic address: tjernigan@ucsd.edu.
Timothy T BrownMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, United States; Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
Hauke BartschMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, United States.
Anders M DaleDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA, United States; Department of Radiology, University of California, San Diego, La Jolla, CA, United States; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, United States; Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States.

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Mapping Individual Cognitive Differences to Neural Variance and School ReadinessR01HD061414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2010 to 2014
$3.3M
Neurobehavioral Contributors to Math Failure: A Reward-Based Learning FrameworkR24HD075489 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2012 to 2015
$2.2M
NICHD NIH HHS R01 HD061414NICHD NIH HHS R24 HD075489NIDA NIH HHS RC2 DA029475
6 · The paper itself

Abstract

Based on the Huttenlocher lecture, this article describes the need for a more integrative scientific paradigm for addressing important questions raised by key observations made over 2 decades ago. Among these are the early descriptions by Huttenlocher of variability in synaptic density in cortex of postmortem brains of children of different ages and the almost simultaneous reports of cortical volume reductions on MR imaging in children and adolescents. In spite of much progress in developmental neurobiology, developmental cognitive neuroscience, and behavioral and imaging genetics, we still do not know how these early observations relate to each other. It is argued that large scale, collaborative research programs are needed to establish the associations between behavioral differences among children and imaging biomarkers, and to link the latter to cellular changes in the developing brain. Examples of progress and challenges remaining are illustrated with data from the Pediatric Imaging, Neurocognition, and Genetics Project (PING).

Indexed as

Neuronal PlasticityAdolescentAdultBrain MappingCerebral CortexChildHumansMagnetic Resonance ImagingNeurosciencesOrgan SizeTheory of MindBehavioral phenotypeBrain developmentCortical surface areaCortical thicknessMagnetic resonance imagingSynaptic pruning

Identifiers

PMID26347228
PMCPMC4762760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.