ArticleThe Journal of cell biology2015
The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Proteomic Characterization of Spinal Cord Myelin in the Mouse.ASN neuro · 2026Article
- Prevalence and Clinical Phenotypes of Headache in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: The MOGHEAD Study.Pain research & management · 2026Observational
- Article
- In Silico Modeling of Myelin Oligodendrocyte Glycoprotein Disulfide Bond Reduction by Phosphine-Borane Complexes.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Pain research & management · 2023Review
- Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia.Cellular and molecular neurobiology · 2022Review
- Differences in Neuropathic Pain and Radiological Features Between AQP4-ON, MOG-ON, and IDON.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Mesenchymal stem cells for regenerative medicine in central nervous system.Frontiers in neuroscience · 2022Review
- Detection of MOG-IgG by cell-based assay: moving from discovery to clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia.Frontiers in psychiatry · 2020Review
- The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay.Frontiers in cellular neuroscience · 2020Article
- Pain in NMOSD and MOGAD: A Systematic Literature Review of Pathophysiology, Symptoms, and Current Treatment Strategies.Frontiers in neurology · 2020Review
- Myelin oligodendrocyte glycoprotein antibodies in neurological disease.Nature reviews. Neurology · 2019Review
- The Absolute Number of Oligodendrocytes in the Adult Mouse Brain.Frontiers in neuroanatomy · 2018Article
- Defining distinct features of anti-MOG antibody associated central nervous system demyelination.Therapeutic advances in neurological disorders · 2018Review
- An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.Frontiers in cellular neuroscience · 2018Review
- Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases.Frontiers in immunology · 2017Review
- Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations.Journal of neuroscience research · 2016Review
- Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact function of MOG has remained unknown, with MOG knockout mice displaying normal myelin ultrastructure and no apparent specific phenotype. In this paper, we identify nerve growth factor (NGF) as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. Deletion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord. Binding of NGF to MOG may offer widespread implications into mechanisms that underlie pain pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.