ArticleMultidisciplinary respiratory medicine2015
Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy in Cypriot adolescents: a case-control study.
Article in Multidisciplinary respiratory medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.PLoS medicine · 2017Pooled it
- Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.International journal of molecular sciences · 2024Article
- Association of polymorphisms of vitamin D gene in children with asthma and allergic rhinitis - Hospital based study.Heliyon · 2024Article
- Exploring the Influence ofJournal of personalized medicine · 2023Article
- Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study.BMC pulmonary medicine · 2023Article
- Review
- Article
- Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma.Frontiers in pediatrics · 2022Article
- Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021Review
- Article
- Association of vitamin D receptor gene polymorphisms in North Indian children with asthma: a case-control study.International journal of molecular epidemiology and genetics · 2021Article
- Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients.Journal of immunology research · 2021Article
- Association of vitamin D gene polymorphisms in children with asthma - A systematic review.Heliyon · 2020Review
- Article
- Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population.BMC oral health · 2020Article
- The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis.International journal of inflammation · 2020Article
- The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.Pediatric allergy, immunology, and pulmonology · 2019Article
- Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots.Molecular biology reports · 2019Article
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- Vitamin D Receptor Gene Polymorphisms Are Associated With Leprosy in Southern Brazil.Frontiers in immunology · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms in the vitamin D receptor (VDR) gene have been studied in immune-related disorders either as independent contributors or in combination with vitamin D concentration. Vitamin D and VDR have been independently linked to asthma susceptibility. We investigated whether VDR variants were associated independently or in relation to vitamin D levels with asthma in Cypriot adolescents.
methodsWe studied 190 current wheezers, 69 of which were categorized as active asthmatics and 671 healthy controls. We determined three VDR genotypes (BsmI, TaqI, ApaI) and measured serum 25(OH)D levels. Logistic regression and stratified analyses by the presence of hypovitaminosis D (≤20 ng/ml) were used to evaluate the association of the VDR variants with asthma.
resultsThe distribution of TaqI genotypes was significantly different between controls and current wheezers (p = 0.030) or active asthmatics (p = 0.014). The tt genotype was over-represented in wheezers (19.2 %) and asthmatics (21.3 %) compared to respective controls (12.9 %). No difference was observed between controls, current wheezers and active asthmatics in the genotypic distribution of BsmI and ApaI polymorphic sites. After stratification by the presence of hypovitaminosis D, a significant association was detected between tt genotype of TaqI polymorphism with wheezing (OR: 1.97, 95 % CI: 1.12, 3.46) and asthma (OR: 2.37, 95CI%: 1.02, 5.52) only in those with normal vitamin D levels (>20 ng/ml) but not in subjects with low vitamin D.
conclusionsThe minor TaqI genotype of VDR is associated with asthma in Cypriot adolescents. This polymorphism may contribute to asthma susceptibility primarily under conditions of normal vitamin D levels (>20 ng/ml).
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