ArticlePituitary2016
Determination of nighttime salivary cortisol during pregnancy: comparison with values in non-pregnancy and Cushing's disease.
Article in Pituitary, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Pooled it
- Pregnancy-induced Cushing syndrome mediated by overexpressingJCEM case reports · 2026Article
- Article
- A case of recurrent Cushing's disease with optimised perinatal outcomes.Endocrinology, diabetes & metabolism case reports · 2025Article
- Successful Medical Management of Cushing Disease With Metyrapone Throughout Pregnancy: A Report of 2 Cases.JCEM case reports · 2025Article
- Cushing syndrome.Nature reviews. Disease primers · 2025Review
- Cushing's Syndrome Missed in Pregnancy.Cureus · 2024Article
- Article
- Cushing's Syndrome in Pregnancy Secondary to Adrenocortical Adenoma: A Case Series and Review.Endocrinology, diabetes & metabolism · 2024Article
- Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome.Journal of the Endocrine Society · 2023Article
- Pitfalls in the Diagnosis and Management of Hypercortisolism (Cushing Syndrome) in Humans; A Review of the Laboratory Medicine Perspective.Diagnostics (Basel, Switzerland) · 2023Review
- Surgical treatment of adrenal tumors during pregnancy.Reviews in endocrine & metabolic disorders · 2023Review
- Emerging diagnostic methods and imaging modalities in cushing's syndrome.Frontiers in endocrinology · 2023Review
- Approach to the Patient: Diagnosis of Cushing Syndrome.The Journal of clinical endocrinology and metabolism · 2022Article
- The diagnosis and management of Cushing's syndrome in pregnancy.Journal of neuroendocrinology · 2022Review
- Persistent vs Recurrent Cushing's Disease Diagnosed Four Weeks Postpartum.Case reports in endocrinology · 2022Article
- Cushing syndrome in pregnancy, diagnosed after delivery.Yeungnam University journal of medicine · 2021Article
- Glucocorticoids in pregnancy.Obstetric medicine · 2020Review
- Endocrine causes of hypertension in pregnancy.Gland surgery · 2020Review
- Cushing's Disease.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNighttime salivary cortisol (NSC) has been proposed for the diagnosis of Cushing's syndrome during pregnancy. However, reference values for NCS in pregnant women have not been adequately determined. The aim of this study was to determine the reference values of NSC in the three gestational trimesters in order to help distinguish physiological from pathological hypercortisolism during pregnancy.
methodsThis prospective and retrospective study evaluated 85 pregnant women in whom samples were collected in the first, second and/or third gestational trimester (pregnancy group), 33 non-pregnant women (control group), and 25 non-pregnant women with Cushing's disease (CD group). NSC was measured by enzyme-linked immunosorbent assay.
resultsNSC increased progressively during pregnancy, reaching maximum levels on the third trimester (median 2.1-fold increase compared with controls, p < 0.001). Reference values for NSC were determined and the upper limits on each gestational trimester were: first trimester 0.25 µg/dL (6.9 nmol/L), second trimester 0.26 µg/dL (7.2 nmol/L), and third trimester 0.33 µg/dL (9.1 nmol/L). Cutoff values that separated the CD group from the three trimesters in the pregnancy groups were, respectively, 0.255 µg/dL (7.0 nmol/L), 0.260 µg/dL (7.2 nmol/L), and 0.285 µg/dL (7.9 nmol/L). Comparison of NSC cutoff values in pregnant women with CD patients showed high sensitivity and specificity in all three trimesters.
conclusionsWe established cutoff values for determination of NSC which can be useful for pregnant women with a diagnostic suspicion of CD.
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Registered trials
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