Evidence map›Paper›PMID 26346368›Full record

ArticleNeuropsychiatric disease and treatment2015

Serum 25-hydroxyvitamin D predicts cognitive performance in adults.

Hala Darwish, Pia Zeinoun, Husam Ghusn, Brigitte Khoury, Hani Tamim, Samia J Khoury

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03610139 (Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03610139 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients: A Single-Blind Randomized Clinical Trial

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2018 to 2022Enrolled162ConditionsMultiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Clinically Isolated Syndrome, Clinically Isolated Syndrome, CNS DemyelinatingArmsVitamin D3
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Nuclear hormone receptors in demyelinating diseases.Journal of neuroendocrinology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hala DarwishHariri School of Nursing, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Pia ZeinounPsychiatry Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Husam GhusnInternal Medicine Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon ; Geriatrics Department, Ain Wazein Hospital, El Chouf, Lebanon.
Brigitte KhouryPsychiatry Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Hani TamimClinical Research Institute, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Samia J KhouryNeurology Department, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is an endogenous hormone known to regulate calcium levels in the body and plays a role in cognitive performance. Studies have shown an association between vitamin D deficiency and cognitive impairment in older adults. Lebanon has a high 25-hydroxyvitamin D (25(OH)D) deficiency prevalence across all age groups.

methodsIn this cross-sectional study, we explored the cognitive performance and serum 25(OH)D levels using an electrochemoluminescent immunoassay in 254 older (>60 years) as well as younger (30-60 years) adults. Subjects' characteristics, including age, years of education, wearing of veil, alcohol consumption, smoking, and physical exercise, were collected. Participants were screened for depression prior to cognitive screening using the Montreal Cognitive Assessment Arabic version. Visuospatial memory was tested using the Rey Complex Figure Test and Recognition Trial, and speed of processing was assessed using the Symbol Digit Modalities test.

resultsPearson's correlation and stepwise linear regression analyses showed that a low vitamin D level was associated with greater risk of cognitive impairment in older as well as younger adults.

conclusionThese findings suggest that correction of vitamin D needs to be explored as an intervention to prevent cognitive impairment. Prospective longitudinal studies are needed to ascertain the effect of such interventions.

Indexed as

agingcognitive functionneuro-psychological function

Identifiers

PMID26346368
PMCPMC4556248

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.