ArticleVeterinary research2015
Piscine orthoreovirus (PRV) in red and melanised foci in white muscle of Atlantic salmon (Salmo salar).
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Melanized Focal Changes in the Fillets of Farmed Atlantic Salmon: A Clinical Report From a Deep-Sea Production Site.Journal of fish diseases · 2026Article
- Melanisation in Salmonid Skeletal Muscle: A Review.Journal of fish diseases · 2025Review
- Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics.Cell and tissue research · 2024Article
- Eumelanin Detection in Melanized Focal Changes but Not in Red Focal Changes on Atlantic Salmon (International journal of molecular sciences · 2023Article
- In-depth health surveillance and clinical nutrition in farmed Atlantic salmon: a strategic attempt to detect and mitigate an HSMI outbreak.Veterinary research · 2023Article
- Type II Grass Carp Reovirus Infects Leukocytes but Not Erythrocytes and Thrombocytes in Grass Carp (Viruses · 2021Article
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- PRV-1 Infected Macrophages in Melanized Focal Changes in White Muscle of Atlantic Salmon (Frontiers in immunology · 2021Article
- Dynamics of Polarized Macrophages and Activated CD8Frontiers in immunology · 2021Article
- Dissemination ofPathogens (Basel, Switzerland) · 2020Article
- Erythroid Progenitor Cells in Atlantic Salmon (Viruses · 2019Article
- Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV).Journal of fish diseases · 2019Article
- Piscine orthoreovirus sequences in escaped farmed Atlantic salmon in Washington and British Columbia.Virology journal · 2019Article
- Detection of Salmonid IgM Specific to theFrontiers in immunology · 2019Article
- Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects.Scientific reports · 2017Article
- Viral Protein Kinetics of Piscine Orthoreovirus Infection in Atlantic Salmon Blood Cells.Viruses · 2017Article
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Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanised focal changes (black spots) are common findings in the white skeletal muscle of seawater-farmed Atlantic salmon (Salmo salar). Fillets with melanised focal changes are considered as lower quality and cause large economic losses. It has been suggested that red focal changes (red spots) precede the melanised focal changes. In the present work, we examined different populations of captive and wild salmon for the occurrence of both types of changes, which were investigated for the presence of different viruses by immunohistochemistry and RT-qPCR. The occurrence of red or melanised foci varied significantly between the populations, from none in wild fish control group, low prevalence of small foci in fish kept in in-house tanks, to high prevalence of large foci in farm-raised salmon. Large amounts of Piscine orthoreovirus (PRV) antigen were detected in all foci. No other viruses were detected. Red focal changes contained significantly higher levels of PRV RNA than apparently non-affected areas in white muscle of the same individuals. Some changes displayed a transient form between a red and melanised pathotype, indicating a progression from an acute to a chronic manifestation. We conclude that PRV is associated with the focal pathological changes in the white muscle of farmed Atlantic salmon and is a premise for the development of focal melanised changes.
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