Hierarchical Classes Analysis (HICLAS): A novel data reduction method to examine associations between biallelic SNPs and perceptual organization phenotypes in schizophrenia.

Jamie Joseph, Michael A Gara, Steven M Silverstein

Open access · goldAbstract read

In one paragraph

Article in Schizophrenia research. Cognition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 96% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jamie JosephRutgers University Graduate School of Biomedical Sciences, 675 Hoes Lane, Piscataway, NJ 08854, USA ; Rutgers University Behavioral Health Care, 151 Centennial Ave, Piscataway, NJ 08854, USA.

Michael A GaraRutgers University Behavioral Health Care, 151 Centennial Ave, Piscataway, NJ 08854, USA ; Rutgers-Robert Wood Johnson Medical School, 671 Hoes Lane, Piscataway, NJ 08854, USA.

Steven M SilversteinRutgers University Behavioral Health Care, 151 Centennial Ave, Piscataway, NJ 08854, USA ; Rutgers-Robert Wood Johnson Medical School, 671 Hoes Lane, Piscataway, NJ 08854, USA.

Rutgers, The State University of New Jersey · US

Funding

Perceptual Organization Dysfunction as a Biomarker of SchizophreniaR01MH093439 · NIMH · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI SILVERSTEIN, STEVEN M · 2011 to 2015

$2.1M

NIMH NIH HHS R01 MH093439

6 · The paper itself

Abstract

The power of SNP association studies to detect valid relationships with clinical phenotypes in schizophrenia is largely limited by the number of SNPs selected and non-specificity of phenotypes. To address this, we first assessed performance on two visual perceptual organization tasks designed to avoid many generalized deficit confounds, Kanizsa shape perception and contour integration, in a schizophrenia patient sample. Then, to reduce the total number of candidate SNPs analyzed in association with perceptual organization phenotypes, we employed a two-stage strategy: first

Indexed as

Data reductionHierarchical Classes Analysis (HICLAS)Perceptual organization phenotypesSchizophreniaSNP

Identifiers

PMID26346124

DOI10.1016/j.scog.2015.03.003

PMCPMC4559868

OpenAlexW2112935226

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.