Evidence map›Paper›PMID 26346038›Full record

ArticleJournal of medical screening2015

Cervical cytology and the diagnosis of cervical cancer in older women.

Rebecca Landy, Alejandra Castanon, Nick Dudding, Anita Wey Wey Lim, Antony Hollingworth, Willie Hamilton, Peter D Sasieni

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical screening, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. No association between breast pain and breast cancer: a prospective cohort study of 10 830 symptomatic women presenting to a breast cancer diagnostic clinic.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rebecca LandyQueen Mary University of London, Charterhouse Square, London, UK.
Alejandra CastanonQueen Mary University of London, Charterhouse Square, London, UK.
Nick DuddingSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Anita Wey Wey LimQueen Mary University of London, Charterhouse Square, London, UK.
Antony HollingworthWhipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Willie HamiltonCollege House, St Luke's Campus, Exeter, UK.
Peter D SasieniQueen Mary University of London, Charterhouse Square, London, UK p.sasieni@qmul.ac.uk.
Queen Mary University of London · GBSheffield Teaching Hospitals NHS Foundation Trust · GBUniversity of Exeter · GBWhipps Cross University Hospital · GB

Funding

Cancer Research UK 16892Cancer Research UK C8162/10406Cancer Research UK C8162/12537
6 · The paper itself

Abstract

objectivesMost non-screen-detected cervical cancers are advanced stage. We assess the potential for cytology to expedite diagnosis when used outside of routine call and recall screening for cervical cancer.

methodsTwo cohorts of women with cytology that did not appear to have been taken as part of routine screening, nested within a census of cervical cytology, in England between April 2007 and March 2010 were studied: 93,322 women aged 40-69 at first cytology, and 14,668 women aged ≥70. The diagnostic performance of high grade cervical squamous intraepithelial lesion (HSIL) or worse cytology was estimated. We also estimated case-fatality from stage distribution in women aged ≥66 with and without cytology in the year prior to diagnosis.

resultsThere were 259 cancers diagnosed in women aged 40-69 at first cytology, and 78 in women aged ≥70. The sensitivity of cytology ≥ HSIL for cancer was 89% and 83% respectively, and the number of women needed to test to identify one cancer was 404 (95% confidence interval [CI]: 355-462) and 226 (95% CI: 177-292) respectively. Women aged ≥66 with cytology within a year of diagnosis had earlier stage cancers than those without, corresponding to a 17-22% reduction in case fatality.

conclusionsCervical cytology is an excellent identifier of cancer among women tested outside routine screening call and recall. Its use as a triage tool, for instance in women with vague gynaecological symptoms, could facilitate earlier stage diagnosis and reduce cervical cancer mortality.

Indexed as

AdultAgedCytological TechniquesEarly Detection of CancerEnglandFemaleHumansMass ScreeningMiddle AgedSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsCervical cancercervical cytologyearly diagnosispap testpositive predictive valuesensitivityspecificitysurvival

Identifiers

PMID26346038
PMCPMC4638314
OpenAlexW2190318604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.