ReviewPediatric cardiology2016
A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates.
Review in Pediatric cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Modelling the time-resolved modulations of cardiac activity in rats: A study on pharmacological autonomic stimulation.The Journal of physiology · 2026Article
- Management of arterial hypotension in critically Ill children: a narrative review and practical approach.Frontiers in pediatrics · 2026Review
- Dose-related systemic and cerebral hemodynamic effects of norepinephrine in newborn piglets with hypoxia-reoxygenation.Pediatric research · 2025Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Observational
- Dobutamine-induced alternations in cerebral blood flow of healthy adults: a 3D pseudocontinuous arterial spin labeling study.BMC medicine · 2023Article
- Editorial: Autonomic nervous system and cardiovascular risk.Frontiers in neuroscience · 2023Article
- A new physiologic-based integrated algorithm in the management of neonatal hemodynamic instability.European journal of pediatrics · 2022Review
- Management of systemic hypotension in term infants with persistent pulmonary hypertension of the newborn: an illustrated review.Archives of disease in childhood. Fetal and neonatal edition · 2021Review
- Genetic background of high blood pressure is associated with reduced mortality in premature neonates.Archives of disease in childhood. Fetal and neonatal edition · 2020Article
- Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life.British journal of clinical pharmacology · 2020Article
- Validity of Biomarkers of Early Circulatory Impairment to Predict Outcome: A Retrospective Analysis.Frontiers in pediatrics · 2019Article
- Cardiovascular Supportive Therapies for Neonates With Asphyxia - A Literature Review of Pre-clinical and Clinical Studies.Frontiers in pediatrics · 2018Review
- Understanding the Stability of Dopamine and Dobutamine Over 24 h in Simulated Neonatal Ward Conditions.Paediatric drugs · 2017Article
- Hemodynamic and metabolic effects of a new pediatric dobutamine formulation in hypoxic newborn pigs.Pediatric research · 2017Article
- Clinical Pharmacology Studies in Critically Ill Children.Pharmaceutical research · 2017Review
- Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets.Pediatric research · 2016Article
- Experts' recommendations for the management of cardiogenic shock in children.Annals of intensive care · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its discovery in 1975 dobutamine has been used off-label for treating hemodynamic insufficiency in newborns and children. We present a structured literature review of pharmacokinetic and pharmacodynamic data for dobutamine in the pediatric population. Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria. Where possible, results for the pharmacodynamic and pharmacokinetic effect of dobutamine were reported as pooled data. Forty-six papers met the inclusion criteria. With regard to pharmacodynamic data a number of studies reported significant increases in a number of clinical parameters such as heart rate, blood pressure, cardiac output across a wide range of pediatric populations. With regard to pharmacokinetic data studies reported that the infusion rate was positively correlated to plasma dobutamine concentration. There was great variability with regard to dobutamine clearance between individuals and as to whether it followed first- or zero-order elimination kinetics. While the pharmacodynamic effects of dobutamine appear to reflect the pharmacological profile of the drug, the pharmacokinetic data are difficult to interpret due to inhomogeneity between study populations ages, comorbidities, dobutamine dosages and methodologies. High-quality prospective pharmacokinetic and pharmacodynamic data especially in newborns are urgently required prior to a large randomized study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.