Evidence map›Paper›PMID 26345641›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2015

Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients.

Renata Ferrari, Laura M O Caram, Marcia M Faganello, Fernanda F Sanchez, Suzana E Tanni, Irma Godoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  13. Intramuscular and Intermuscular Abdominal Fat Infiltration in COPD: A Propensity Score Matched Study.International journal of chronic obstructive pulmonary disease · 2021
    Article
  14. Article
  15. Article
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  18. Frailty trajectories in adult lung transplantation: A cohort study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Renata FerrariBotucatu Medical School, Department of Internal Medicine, Pneumology Area, Botucatu, São Paulo, Brazil.
Laura M O CaramBotucatu Medical School, Department of Internal Medicine, Pneumology Area, Botucatu, São Paulo, Brazil.
Marcia M FaganelloPaulista State University, Department of Physiotherapy and Occupational Therapy, Marilia, São Paulo, Brazil.
Fernanda F SanchezFederal University of Amazonas, Department of Physiotherapy, Manaus, Amazonas, Brazil.
Suzana E TanniBotucatu Medical School, Department of Internal Medicine, Pneumology Area, Botucatu, São Paulo, Brazil.
Irma GodoyBotucatu Medical School, Department of Internal Medicine, Pneumology Area, Botucatu, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV1%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (-3.09 [-5.99, -0.18]; P=0.04) and triceps pulley (-1.31 [-2.35, -0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (-0.06 [-0.11, -0.01]; P=0.02). Our results showed negative association between peripheral muscle mass (evaluated by CT) and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles.

Indexed as

Muscle, SkeletalMuscle StrengthAgedBiomarkersC-Reactive ProteinFemaleForced Expiratory VolumeHumansInflammation MediatorsLungMaleMiddle AgedMuscle WeaknessNutritional StatusOrgan SizePulmonary Disease, Chronic ObstructiveBiomarkersC-Reactive ProteinInflammation MediatorsTumor Necrosis Factor-alphaInflammationskeletal muscleX-Ray Computed Tomography

Identifiers

PMID26345641
PMCPMC4531022

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.