ArticleScientific reports2015
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.EMBO reports · 2026Article
- The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity.bioRxiv : the preprint server for biology · 2025Article
- Spatial and functional separation of mTORC1 signalling in response to different amino acid sources.Nature cell biology · 2024Article
- Inhibition of WNK Kinases in NK Cells Disrupts Cellular Osmoregulation and Control of Tumor Metastasis.Journal of innate immunity · 2024Article
- Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.Nature cell biology · 2023Article
- High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells.Endocrine · 2022Article
- Passive coupling of membrane tension and cell volume during active response of cells to osmosis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.Molecular cell · 2021Article
- mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases.Frontiers in aging · 2021Review
- The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging.Frontiers in aging · 2021Review
- The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back.Frontiers in cell and developmental biology · 2021Review
- Regulation of mTORC1 by Upstream Stimuli.Genes · 2020Review
- The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection.eLife · 2020Article
- Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α.Molecular cell · 2020Article
- Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.The Journal of biological chemistry · 2020Article
- Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex.Molecular and cellular biology · 2019Article
- Role of mTOR Signaling in Female Reproduction.Frontiers in endocrinology · 2019Review
- Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status.Cell death discovery · 2019Article
- mTORC1 senses stresses: Coupling stress to proteostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
mTOR complex 1 (mTORC1) regulates cell growth and metabolism. mTORC1 activity is regulated via integration of positive growth-promoting stimuli and negative stress stimuli. One stress cells confront in physiological and pathophysiological contexts is hyperosmotic stress. The mechanism by which hyperosmotic stress regulates mTORC1 activity is not well understood. We show here that mild hyperosmotic stress induces a rapid and reversible inactivation of mTORC1 via a mechanism involving multiple upstream signaling pathways. We find that hyperosmotic stress causes dynamic changes in TSC2 phosphorylation by upstream kinases, such as Akt, thereby recruiting TSC2 from the cytoplasm to lysosomes where it acts on Rheb, the direct activator of mTORC1. This work puts together a signaling pathway whereby hyperosmotic stress inactivates mTORC1.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.