Evidence map›Paper›PMID 26345289›Full record

ArticleEpidemiology and infection2016

Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility.

E Benedetti, R S Daniels, A Pontoriero, M Russo, M Avaro, A Czech, A Campos, N Periolo, V Gregory, J W McCauley and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

E BenedettiNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
R S DanielsThe Francis Crick Institute,Mill Hill Laboratory,The Ridgeway,Mill Hill,London,UK.
A PontorieroNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
M RussoNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
M AvaroNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
A CzechNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
A CamposNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
N PerioloNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
V GregoryThe Francis Crick Institute,Mill Hill Laboratory,The Ridgeway,Mill Hill,London,UK.
J W McCauleyThe Francis Crick Institute,Mill Hill Laboratory,The Ridgeway,Mill Hill,London,UK.
E G BaumeisterNational Influenza Centre PAHO/WHO,Servicio Virosis Respiratorias,Departamento Virología,Instituto Nacional de Enfermedades Infecciosas,ANLIS 'Carlos G. Malbrán',Buenos Aires,Argentina.
Administración Nacional de Laboratorios e Institutos de Salud · ARThe Francis Crick Institute · GB

Funding

Medical Research Council MC_U117512723
6 · The paper itself

Abstract

The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.

Indexed as

Drug Resistance, ViralPopulation SurveillanceAntiviral AgentsArgentinaHemagglutininsHumansInfluenza A virusInfluenza B virusInfluenza, HumanNeuraminidaseViral ProteinsAntiviral AgentsHemagglutininsNeuraminidaseViral ProteinsInfluenzainfluenza vaccinesresistance to drugsrespiratory infectionssurveillance

Identifiers

PMID26345289
PMCPMC4762242
OpenAlexW1787726470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.