ArticleNeuroscience bulletin2015
Increasing the effectiveness of intracerebral injections in adult and neonatal mice: a neurosurgical point of view.
Article in Neuroscience bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
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- A low-cost device for cryoanesthesia of neonatal rodents.HardwareX · 2023Article
- Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.eLife · 2022Article
- Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure.Frontiers in aging neuroscience · 2022Article
- Analytical Modeling of Flowrate and Its Maxima in Electrochemical Bioelectronics with Drug Delivery Capabilities.Research (Washington, D.C.) · 2022Article
- Newborn mice form lasting CA2-dependent memories of their mothers.Cell reports · 2021Article
- Adult-Born Hippocampal Neurons Undergo Extended Development and Are Morphologically Distinct from Neonatally-Born Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Anterior Thalamic Excitation and Feedforward Inhibition of Presubicular Neurons Projecting to Medial Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains.Journal of visualized experiments : JoVE · 2018Article
- Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum.Nature communications · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral injections of tracers or viral constructs in rodents are now commonly used in the neurosciences and must be executed perfectly. The purpose of this article is to update existing protocols for intracerebral injections in adult and neonatal mice. Our procedure for stereotaxic injections in adult mice allows the investigator to improve the effectiveness and safety, and save time. Furthermore, for the first time, we describe a two-handed procedure for intracerebral injections in neonatal mice that can be performed by a single operator in a very short time. Our technique using the stereotaxic arm allows a higher precision than freehand techniques previously described. Stereotaxic injections in adult mice can be performed in 20 min and have >90% efficacy in targeting the injection site. Injections in neonatal mice can be performed in 5 min. Efficacy depends on the difficulty of precisely localizing the injection sites, due to the small size of the animal. We describe an innovative, effortless, and reproducible surgical protocol for intracerebral injections in adult and neonatal mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.