ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2015
In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil.
Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- A First-in-Human Phase 1 Randomized Single and Multiple Ascending Dose Study of RPh201 in Healthy Volunteers.Clinical pharmacology in drug development · 2020Trial
- Effect of essential oils fromFrontiers in parasitology · 2025Article
- Essential Oils and Terpenic Compounds as Potential Hits for Drugs against Amitochondriate Protists.Tropical medicine and infectious disease · 2023Review
- Overview of Chios Mastic Gum (Nutrients · 2022Review
- Valorization of MoroccanTheScientificWorldJournal · 2022Article
- Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action.Frontiers in pharmacology · 2021Review
- Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant ofAntibiotics (Basel, Switzerland) · 2020Article
- Biological Activities of Essential Oils from Leaves ofAntibiotics (Basel, Switzerland) · 2020Article
- In vitro Antimicrobial Activity of Essential Oil Extracted from Leaves ofPlants (Basel, Switzerland) · 2020Article
- Therapeutic effects of Iranian herbal extracts against Trichomonas vaginalisIranian biomedical journal · 2017Article
- The antitrichomonal efficacy of garlic and metronidazole against Trichomonas gallinae infecting domestic pigeons.Parasitology research · 2014Article
- In Vitro Activity ofIranian journal of parasitologyArticle
- Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.In vivo (Athens, Greece)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. Metronidazole is the drug of choice for T. vaginalis infections. The increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. Pistacia lentiscus mastic and Ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. The present study was carried out to investigate the in vitro effects of P. lentiscus mastic and O. basilicum oil on T. vaginalis trophozoites. The effects of different concentrations of P. lentiscus mastic (15, 10 and 5 mg/ml) and different concentrations of O. basilicum oil (30, 20 and 10 μg/ml) on multiplication of trophozoites at different time points (after 24, 48, 72 and 96 h) were determined, also morphological changes were reported by transmission electron microscopy (TEM). The results showed that both plants caused an inhibition of growth of T. vaginalis trophozoites. The minimal lethal concentration of P. lentiscus mastic was 15 mg/ml after 24 h incubation, 10 mg/ml after 48 h and 5 mg/ml after 96 h. The minimal lethal concentration of O. basilicum oil was 30 μg/ml after 24 h incubation, 20 μg/ml after 48 h and 10 μg/ml after 96 h. TEM study of trophozoites treated by P. lentiscus mastic or by O. basilicum oil showed considerable damage of the membrane system of the trophozoites, and extensive vacuolization of the cytoplasm. These results highly suggest that P. lentiscus mastic and O. basilicum oil may be promising phytotherapeutic agents for trichomoniasis treatment.
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