Evidence map›Paper›PMID 26344947›Full record

ArticleVaccines2015

EBV-Associated Cancer and Autoimmunity: Searching for Therapies.

Giovanni Capone, Candida Fasano, Guglielmo Lucchese, Michele Calabrò, Darja Kanduc

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Non-viralFrontiers in immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Giovanni CaponeDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. g.capone@biologia.uniba.it.
Candida FasanoDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. candida.fasano@gmail.com.
Guglielmo LuccheseBrain and Language Laboratory, Free University of Berlin, 14195 Berlin, Germany. guglielmo.lucchese@hotmail.com.
Michele CalabròDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. michele.calabro@hotmail.it.
Darja KanducDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy. darja.kanduc@uniba.it.
University of Bari Aldo Moro · ITFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies.

Indexed as

anti-EBV vaccineautoimmunitycancerEBV EBNA1low-similarity peptidespeptide matchingpeptide-therapy

Identifiers

PMID26344947
PMCPMC4494242
OpenAlexW2043356262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.